1pvg: Difference between revisions

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[[Image:1pvg.gif|left|200px]]<br /><applet load="1pvg" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1pvg.gif|left|200px]]
caption="1pvg, resolution 1.80&Aring;" />
 
'''Crystal Structure of the ATPase region of Saccharomyces Cerevisiae topoisomerase II'''<br />
{{Structure
|PDB= 1pvg |SIZE=350|CAPTION= <scene name='initialview01'>1pvg</scene>, resolution 1.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER'>ANP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3]
|GENE= TOP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
}}
 
'''Crystal Structure of the ATPase region of Saccharomyces Cerevisiae topoisomerase II'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1PVG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ANP:'>ANP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PVG OCA].  
1PVG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PVG OCA].  


==Reference==
==Reference==
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187., Classen S, Olland S, Berger JM, Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10629-34. Epub 2003 Sep 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12963818 12963818]
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187., Classen S, Olland S, Berger JM, Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10629-34. Epub 2003 Sep 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12963818 12963818]
[[Category: DNA topoisomerase (ATP-hydrolyzing)]]
[[Category: DNA topoisomerase (ATP-hydrolyzing)]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: ghkl atpase domain]]
[[Category: ghkl atpase domain]]


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