1pw6: Difference between revisions

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[[Image:1pw6.gif|left|200px]]<br /><applet load="1pw6" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1pw6.gif|left|200px]]
caption="1pw6, resolution 2.60&Aring;" />
 
'''Low Micromolar Small Molecule Inhibitor of IL-2'''<br />
{{Structure
|PDB= 1pw6 |SIZE=350|CAPTION= <scene name='initialview01'>1pw6</scene>, resolution 2.60&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=FRB:2-CYCLOHEXYL-N-(2-{4-[5-(2,3-DICHLORO-PHENYL)-2H-PYRAZOL-3-YL]-PIPERIDIN-1-YL}-2-OXO-ETHYL)-2-GUANIDINO-ACETAMIDE'>FRB</scene>
|ACTIVITY=
|GENE= IL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Low Micromolar Small Molecule Inhibitor of IL-2'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1PW6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=FRB:'>FRB</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PW6 OCA].  
1PW6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PW6 OCA].  


==Reference==
==Reference==
Potent small-molecule binding to a dynamic hot spot on IL-2., Thanos CD, Randal M, Wells JA, J Am Chem Soc. 2003 Dec 17;125(50):15280-1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14664558 14664558]
Potent small-molecule binding to a dynamic hot spot on IL-2., Thanos CD, Randal M, Wells JA, J Am Chem Soc. 2003 Dec 17;125(50):15280-1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14664558 14664558]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: il-2 interleukin 2 small molecule inhibitor]]
[[Category: il-2 interleukin 2 small molecule inhibitor]]


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