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{{STRUCTURE_2xzb|  PDB=2xzb  |  SCENE=  }}
==Pig Gastric H,K-ATPase with bound BeF and SCH28080==
===Pig Gastric H,K-ATPase with bound BeF and SCH28080===
<StructureSection load='2xzb' size='340' side='right' caption='[[2xzb]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
{{ABSTRACT_PUBMED_21224846}}
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2xzb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XZB FirstGlance]. <br>
==Disease==
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3a3y|3a3y]], [[1iwc|1iwc]], [[1iwf|1iwf]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrogen/potassium-exchanging_ATPase Hydrogen/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.10 3.6.3.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xzb RCSB], [http://www.ebi.ac.uk/pdbsum/2xzb PDBsum]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis.  
[[http://www.uniprot.org/uniprot/ATP4B_PIG ATP4B_PIG]] Note=Parietal cell autoantigen associated with autoimmune gastritis.  
== Function ==
[[http://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG]] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Acid-related gastric diseases are associated with disorder of digestive tract acidification. The gastric proton pump, H(+),K(+)-ATPase, exports H(+) in exchange for luminal K(+) to generate a highly acidic environment in the stomach, and is a main target for acid suppressants. Here, we report the three-dimensional structure of gastric H(+),K(+)-ATPase with bound SCH28080, a representative K(+)-competitive acid blocker, at 7 A resolution based on electron crystallography of two-dimensional crystals. The density of the bound SCH28080 is found near transmembrane (TM) helices 4, 5 and 6, in the luminal cavity. The SCH28080-binding site is formed by the rearrangement of TM helices, which is in turn transmitted to the cytoplasmic domains, resulting in a luminal-open conformation. These results represent the first structural evidence for a binding site of an acid suppressant on H(+),K(+)-ATPase, and the conformational change induced by this class of drugs.


==Function==
Conformational rearrangement of gastric H(+),K(+)-ATPase induced by an acid suppressant.,Abe K, Tani K, Fujiyoshi Y Nat Commun. 2011 Jan;2(1):155. PMID:21224846<ref>PMID:21224846</ref>
[[http://www.uniprot.org/uniprot/ATP4A_PIG ATP4A_PIG]] Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.  


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[2xzb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZB OCA].
</div>


==See Also==
==See Also==
*[[ATPase|ATPase]]
*[[ATPase|ATPase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021224846</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Hydrogen/potassium-exchanging ATPase]]
[[Category: Hydrogen/potassium-exchanging ATPase]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Abe, K.]]
[[Category: Abe, K]]
[[Category: Fujiyoshi, Y.]]
[[Category: Fujiyoshi, Y]]
[[Category: Tani, K.]]
[[Category: Tani, K]]
[[Category: Acid suppressant]]
[[Category: Acid suppressant]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
Retrieved from "https://proteopedia.org/2xzb"