3fb2: Difference between revisions
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==Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.== | |||
<StructureSection load='3fb2' size='340' side='right' caption='[[3fb2]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
==Disease== | <table><tr><td colspan='2'>[[3fb2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FB2 FirstGlance]. <br> | ||
[[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Defects in SPTAN1 are the cause of epileptic encephalopathy early infantile type 5 (EIEE5) [MIM:[http://omim.org/entry/613477 613477]]. EIEE5 is a disorder characterized by seizures associated with hypsarrhythmia profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia.<ref>PMID:20493457</ref> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u5p|1u5p]]</td></tr> | |||
==Function== | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPTA2, SPTAN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fb2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fb2 PDBsum], [http://www.topsan.org/Proteins/NESGC/3fb2 TOPSAN]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Defects in SPTAN1 are the cause of epileptic encephalopathy early infantile type 5 (EIEE5) [MIM:[http://omim.org/entry/613477 613477]]. EIEE5 is a disorder characterized by seizures associated with hypsarrhythmia profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia.<ref>PMID:20493457</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. | [[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. | ||
==See Also== | ==See Also== | ||
*[[Spectrin|Spectrin]] | *[[Spectrin|Spectrin]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Acton, T B | [[Category: Acton, T B]] | ||
[[Category: Ciccosanti, C | [[Category: Ciccosanti, C]] | ||
[[Category: Foote, E L | [[Category: Foote, E L]] | ||
[[Category: Hunt, J F | [[Category: Hunt, J F]] | ||
[[Category: Janjua, H | [[Category: Janjua, H]] | ||
[[Category: Montelione, G T | [[Category: Montelione, G T]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Seetharaman, J | [[Category: Seetharaman, J]] | ||
[[Category: Shastry, R | [[Category: Shastry, R]] | ||
[[Category: Su, M | [[Category: Su, M]] | ||
[[Category: Tong, L | [[Category: Tong, L]] | ||
[[Category: Vorobiev, S M | [[Category: Vorobiev, S M]] | ||
[[Category: Xiao, R | [[Category: Xiao, R]] | ||
[[Category: Actin capping]] | [[Category: Actin capping]] | ||
[[Category: Actin-binding]] | [[Category: Actin-binding]] | ||
| Line 39: | Line 42: | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
[[Category: Non-erythroid alpha chain alpha-ii spectrin]] | [[Category: Non-erythroid alpha chain alpha-ii spectrin]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Protein structure initiative | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Sh3 domain]] | [[Category: Sh3 domain]] | ||
[[Category: Spectrin alpha chain]] | [[Category: Spectrin alpha chain]] | ||
[[Category: Spta2_human]] | [[Category: Spta2_human]] | ||
[[Category: Sptan1]] | [[Category: Sptan1]] | ||
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
Revision as of 13:38, 18 December 2014
Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Acton, T B
- Ciccosanti, C
- Foote, E L
- Hunt, J F
- Janjua, H
- Montelione, G T
- Structural genomic
- Seetharaman, J
- Shastry, R
- Su, M
- Tong, L
- Vorobiev, S M
- Xiao, R
- Actin capping
- Actin-binding
- Brain spectrin
- Calmodulin-binding
- Cytoskeleton
- Fordrin alpha chain
- Hr5563a
- Nesg
- Non-erythroid alpha chain alpha-ii spectrin
- Phosphoprotein
- PSI, Protein structure initiative
- Sh3 domain
- Spectrin alpha chain
- Spta2 human
- Sptan1
- Structural protein
