2yl2: Difference between revisions
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==CRYSTAL STRUCTURE OF HUMAN ACETYL-COA CARBOXYLASE 1, BIOTIN CARBOXYLASE (BC) DOMAIN== | |||
<StructureSection load='2yl2' size='340' side='right' caption='[[2yl2]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
==Disease== | <table><tr><td colspan='2'>[[2yl2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YL2 FirstGlance]. <br> | ||
[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[http://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yl2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yl2 RCSB], [http://www.ebi.ac.uk/pdbsum/2yl2 PDBsum]</span></td></tr> | ||
</table> | |||
==Function== | == Disease == | ||
[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref> | [[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[http://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref> | |||
==See Also== | ==See Also== | ||
*[[Biotin carboxylase|Biotin carboxylase]] | *[[Biotin carboxylase|Biotin carboxylase]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Beltrami, A | [[Category: Beltrami, A]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Delft, F Von | [[Category: Delft, F Von]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Froese, D S | [[Category: Froese, D S]] | ||
[[Category: Krojer, T | [[Category: Krojer, T]] | ||
[[Category: Krysztofinska, E | [[Category: Krysztofinska, E]] | ||
[[Category: Muniz, J R.C | [[Category: Muniz, J R.C]] | ||
[[Category: Oppermann, U | [[Category: Oppermann, U]] | ||
[[Category: Vollmar, M | [[Category: Vollmar, M]] | ||
[[Category: Weigelt, J | [[Category: Weigelt, J]] | ||
[[Category: Yue, W W | [[Category: Yue, W W]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
Revision as of 13:57, 18 December 2014
CRYSTAL STRUCTURE OF HUMAN ACETYL-COA CARBOXYLASE 1, BIOTIN CARBOXYLASE (BC) DOMAIN
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