3lfk: Difference between revisions
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==A reported archaeal mechanosensitive channel is a structural homolog of MarR-like transcriptional regulators== | |||
<StructureSection load='3lfk' size='340' side='right' caption='[[3lfk]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3lfk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_volcanium Thermoplasma volcanium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LFK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TV0762, TVG0766549 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=50339 Thermoplasma volcanium])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lfk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lfk RCSB], [http://www.ebi.ac.uk/pdbsum/3lfk PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Several archaeal mechanosensitive (MS) channels have been reported, including one from Thermoplasma volcanium designated MscTV. Here, we report the crystal structure of MscTV at 1.6-A resolution. Unexpectedly, MscTV was found to be a water-soluble protein exhibiting a winged helix-turn-helix (wHTH) motif, which is the signature of the MarR (multiple antibiotic resistance regulator) family of transcriptional regulators. A cell-based osmotic downshock functional assay demonstrated that MscTV was unable to protect a knockout strain of Escherichia coli from hypoosmotic shock, further indicating that it does not function as a MS channel. We propose this protein be renamed MLPTv for MarR-like protein from T. volcanium. | |||
A reported archaeal mechanosensitive channel is a structural homolog of MarR-like transcriptional regulators.,Liu Z, Walton TA, Rees DC Protein Sci. 2010 Apr;19(4):808-14. PMID:20162616<ref>PMID:20162616</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Thermoplasma volcanium]] | [[Category: Thermoplasma volcanium]] | ||
[[Category: Liu, Z | [[Category: Liu, Z]] | ||
[[Category: Rees, D C | [[Category: Rees, D C]] | ||
[[Category: Walton, T A | [[Category: Walton, T A]] | ||
[[Category: Mechanosensitive channel]] | [[Category: Mechanosensitive channel]] | ||
[[Category: Multiple antibiotic resistance regulator]] | [[Category: Multiple antibiotic resistance regulator]] | ||
Revision as of 14:52, 18 December 2014
A reported archaeal mechanosensitive channel is a structural homolog of MarR-like transcriptional regulators
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