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{{STRUCTURE_3lm8|  PDB=3lm8  |  SCENE=  }}
==Crystal Structure of Thiamine pyrophosphokinase from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR677==
===Crystal Structure of Thiamine pyrophosphokinase from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR677===
<StructureSection load='3lm8' size='340' side='right' caption='[[3lm8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3lm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LM8 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/THIN_BACSU THIN_BACSU]] Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate.  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=VIB:3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM'>VIB</scene></td></tr>
 
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
==About this Structure==
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ihk|3ihk]], [[3k94|3k94]]</td></tr>
[[3lm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LM8 OCA].  
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BSU15800, thiN, yloS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine_diphosphokinase Thiamine diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.2 2.7.6.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lm8 RCSB], [http://www.ebi.ac.uk/pdbsum/3lm8 PDBsum]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/3lm8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Thiamine diphosphokinase]]
[[Category: Thiamine diphosphokinase]]
[[Category: Abashidze, M.]]
[[Category: Abashidze, M]]
[[Category: Acton, T B.]]
[[Category: Acton, T B]]
[[Category: Ciccosanti, C.]]
[[Category: Ciccosanti, C]]
[[Category: Everett, J K.]]
[[Category: Everett, J K]]
[[Category: Foote, E L.]]
[[Category: Foote, E L]]
[[Category: Hunt, J F.]]
[[Category: Hunt, J F]]
[[Category: Kuzin, A.]]
[[Category: Kuzin, A]]
[[Category: Mao, M.]]
[[Category: Mao, M]]
[[Category: Montelione, G T.]]
[[Category: Montelione, G T]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Nair, R.]]
[[Category: Nair, R]]
[[Category: Rost, B.]]
[[Category: Rost, B]]
[[Category: Seetharaman, J.]]
[[Category: Seetharaman, J]]
[[Category: Tong, L.]]
[[Category: Tong, L]]
[[Category: Wang, H.]]
[[Category: Wang, H]]
[[Category: Xiao, R.]]
[[Category: Xiao, R]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Nesg]]
[[Category: Nesg]]
[[Category: Northeast structural genomics consortium]]
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Protein structure initiative]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Structural genomic]]
[[Category: Transferase]]
[[Category: Transferase]]
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