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{{STRUCTURE_3mdb|  PDB=3mdb  |  SCENE=  }}
==Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4==
===Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4===
<StructureSection load='3mdb' size='340' side='right' caption='[[3mdb]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3mdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MDB FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/KI13B_HUMAN KI13B_HUMAN]] Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.<ref>PMID:20194617</ref> [[http://www.uniprot.org/uniprot/ADAP1_HUMAN ADAP1_HUMAN]] GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).<ref>PMID:10448098</ref> <ref>PMID:10333475</ref>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IP9:(2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIOCTANOATE'>IP9</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIF13B, GAKIN, KIAA0639 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), ADAP1, CENTA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mdb RCSB], [http://www.ebi.ac.uk/pdbsum/3mdb PDBsum]</span></td></tr>
[[3mdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDB OCA].  
</table>
 
== Evolutionary Conservation ==
==Reference==
[[Image:Consurf_key_small.gif|200px|right]]
<references group="xtra"/><references/>
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/3mdb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev, A]]
[[Category: Bountra, C.]]
[[Category: Bountra, C]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M]]
[[Category: MacKenzie, F.]]
[[Category: MacKenzie, F]]
[[Category: Park, H.]]
[[Category: Park, H]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Shen, L.]]
[[Category: Shen, L]]
[[Category: Tempel, W.]]
[[Category: Tempel, W]]
[[Category: Tong, Y.]]
[[Category: Tong, Y]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Cytoskeleton]]
[[Category: Cytoskeleton]]
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[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
[[Category: Transport protein-hydrolase activator complex]]
[[Category: Transport protein-hydrolase activator complex]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]

Revision as of 16:46, 18 December 2014

Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4

3mdb, resolution 2.95Å

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