3kh0: Difference between revisions

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{{STRUCTURE_3kh0|  PDB=3kh0  |  SCENE=  }}
==Crystal structure of the Ras-association (RA) domain of RALGDS==
===Crystal structure of the Ras-association (RA) domain of RALGDS===
<StructureSection load='3kh0' size='340' side='right' caption='[[3kh0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3kh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KH0 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/GNDS_HUMAN GNDS_HUMAN]] Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RALGDS, KIAA1308, RGF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kh0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kh0 RCSB], [http://www.ebi.ac.uk/pdbsum/3kh0 PDBsum]</span></td></tr>
[[3kh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KH0 OCA].  
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kh/3kh0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev, A]]
[[Category: Bountra, C.]]
[[Category: Bountra, C]]
[[Category: Crombet, L.]]
[[Category: Crombet, L]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M]]
[[Category: Guan, X.]]
[[Category: Guan, X]]
[[Category: Park, H.]]
[[Category: Park, H]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Shen, Y.]]
[[Category: Shen, Y]]
[[Category: Tempel, W.]]
[[Category: Tempel, W]]
[[Category: Tong, Y.]]
[[Category: Tong, Y]]
[[Category: Wang, H.]]
[[Category: Wang, H]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: Guanine-nucleotide releasing factor]]
[[Category: Guanine-nucleotide releasing factor]]
[[Category: Ras-association domain]]
[[Category: Ras-association domain]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Structural genomics consortium]]

Revision as of 16:58, 18 December 2014

Crystal structure of the Ras-association (RA) domain of RALGDS

3kh0, resolution 2.10Å

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