1qmc: Difference between revisions
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[[Image:1qmc.gif|left|200px]] | [[Image:1qmc.gif|left|200px]] | ||
'''C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES''' | {{Structure | ||
|PDB= 1qmc |SIZE=350|CAPTION= <scene name='initialview01'>1qmc</scene> | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
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'''C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1QMC is a [ | 1QMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMC OCA]. | ||
==Reference== | ==Reference== | ||
Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase., Eijkelenboom AP, Sprangers R, Hard K, Puras Lutzke RA, Plasterk RH, Boelens R, Kaptein R, Proteins. 1999 Sep 1;36(4):556-64. PMID:[http:// | Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase., Eijkelenboom AP, Sprangers R, Hard K, Puras Lutzke RA, Plasterk RH, Boelens R, Kaptein R, Proteins. 1999 Sep 1;36(4):556-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10450096 10450096] | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Plasterk, R H.A.]] | [[Category: Plasterk, R H.A.]] | ||
[[Category: Sprangers, R.]] | [[Category: Sprangers, R.]] | ||
[[Category: | [[Category: aid]] | ||
[[Category: dna-binding protein]] | [[Category: dna-binding protein]] | ||
[[Category: integrase]] | [[Category: integrase]] | ||
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[[Category: src homology 3 (sh3)-like fold]] | [[Category: src homology 3 (sh3)-like fold]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:39:38 2008'' | ||
Revision as of 11:39, 20 March 2008
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C-TERMINAL DNA-BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 42 STRUCTURES
Overview
The structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase has been refined using nuclear magnetic resonance spectroscopy. The protein is a dimer in solution and shows a well-defined dimer interface. The folding topology of the monomer consists of a five-stranded beta-barrel that resembles that of Src homology 3 domains. Compared with our previously reported structure, the structure is now defined far better. The final 42 structures display a back-bone root mean square deviation versus the average of 0.46 A. Correlation of the structure with recent mutagenesis studies suggests two possible models for DNA binding. Proteins 1999;36:556-564.
About this Structure
1QMC is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase., Eijkelenboom AP, Sprangers R, Hard K, Puras Lutzke RA, Plasterk RH, Boelens R, Kaptein R, Proteins. 1999 Sep 1;36(4):556-64. PMID:10450096
Page seeded by OCA on Thu Mar 20 13:39:38 2008
