3ldh: Difference between revisions
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==A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes== | |||
<StructureSection load='3ldh' size='340' side='right' caption='[[3ldh]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
== | <table><tr><td colspan='2'>[[3ldh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Squalus_acanthias Squalus acanthias]. The June 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Lactate Dehydrogenase'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_6 10.2210/rcsb_pdb/mom_2008_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LDH FirstGlance]. <br> | ||
[[3ldh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Squalus_acanthias Squalus acanthias]. The June 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Lactate Dehydrogenase'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_6 10.2210/rcsb_pdb/mom_2008_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDH OCA]. | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ldh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ldh RCSB], [http://www.ebi.ac.uk/pdbsum/3ldh PDBsum]</span></td></tr> | |||
</table> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/3ldh_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Lactate Dehydrogenase|Lactate Dehydrogenase]] | *[[Lactate Dehydrogenase|Lactate Dehydrogenase]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: L-lactate dehydrogenase]] | [[Category: L-lactate dehydrogenase]] | ||
[[Category: Lactate Dehydrogenase]] | [[Category: Lactate Dehydrogenase]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Squalus acanthias]] | [[Category: Squalus acanthias]] | ||
[[Category: Adams, M J | [[Category: Adams, M J]] | ||
[[Category: Buehner, M | [[Category: Buehner, M]] | ||
[[Category: Ford, G C | [[Category: Ford, G C]] | ||
[[Category: Hackert, M L | [[Category: Hackert, M L]] | ||
[[Category: Lentzjunior, P J | [[Category: Lentzjunior, P J]] | ||
[[Category: Rossmann, M G | [[Category: Rossmann, M G]] | ||
[[Category: Smiley, I E | [[Category: Smiley, I E]] | ||
[[Category: Steindel, S J | [[Category: Steindel, S J]] | ||
[[Category: White, J L | [[Category: White, J L]] | ||
[[Category: Choh donor]] | [[Category: Choh donor]] | ||
[[Category: Nad acceptor]] | [[Category: Nad acceptor]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
