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{{STRUCTURE_3klj|  PDB=3klj  |  SCENE=  }}
==Crystal structure of NADH:rubredoxin oxidoreductase from Clostridium acetobutylicum==
===Crystal structure of NADH:rubredoxin oxidoreductase from Clostridium acetobutylicum===
<StructureSection load='3klj' size='340' side='right' caption='[[3klj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3klj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_acetobutylicum Clostridium acetobutylicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KLJ FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/Q9AL95_CLOAB Q9AL95_CLOAB]] Catalyzes the NADH-dependent reduction of rubredoxin (Rd). NADPH is a very poor electron donor compared to NADH. Functions as an intermediate component in the electron transfer chain: NADH->NROR->Rd->FprA1/2. Also functions as an intermediate component in the electron transfer chains from NADH to revRbr and Dfx. Therefore, is a key electron carrier in an efficient multienzyme complex that can scavenge O(2) and reactive oxygen species (ROS), and thus plays an important role in the oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium.<ref>PMID:11444870</ref> <ref>PMID:19124587</ref> <ref>PMID:19084524</ref> <ref>PMID:19118342</ref>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nror, CA_C2448 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1488 Clostridium acetobutylicum])</td></tr>
==About this Structure==
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Rubredoxin--NAD(+)_reductase Rubredoxin--NAD(+) reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.1.1 1.18.1.1] </span></td></tr>
[[3klj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_acetobutylicum Clostridium acetobutylicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLJ OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3klj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3klj RCSB], [http://www.ebi.ac.uk/pdbsum/3klj PDBsum]</span></td></tr>
 
</table>
==Reference==
== Evolutionary Conservation ==
<ref group="xtra">PMID:020017214</ref><references group="xtra"/><references/>
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3klj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Clostridium acetobutylicum]]
[[Category: Clostridium acetobutylicum]]
[[Category: Higuchi, Y.]]
[[Category: Higuchi, Y]]
[[Category: Kawasaki, S.]]
[[Category: Kawasaki, S]]
[[Category: Niimura, Y.]]
[[Category: Niimura, Y]]
[[Category: Nishikawa, K.]]
[[Category: Nishikawa, K]]
[[Category: Shomura, Y.]]
[[Category: Shomura, Y]]
[[Category: Fad-binding protein]]
[[Category: Fad-binding protein]]
[[Category: Gr-fold]]
[[Category: Gr-fold]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/3klj"