3ld1: Difference between revisions

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~~{{STRUCTURE_3ld1| PDB=3ld1 | SCENE= }}~~

==Crystal Structure of IBV Nsp2a==

===Crystal Structure of IBV Nsp2a===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[3ld1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LD1 FirstGlance]. <br>

[[~~http://www.uniprot.org/uniprot/R1A_IBVM R1A_IBVM~~]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [~~ILMVF~~]~~-Q-|-[SGACN~~]. ~~Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1~~''-phosphate (ADRP)-binding function (By similarity). The peptide p16 might be involved in the EGF signaling pathway (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">1a, 1ab ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ld1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ld1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ld1 PDBsum]</span></td></tr>

==~~About this Structure~~==

</table>

[[3ld1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD1 OCA].

__TOC__

</StructureSection>

[[Category: Viruses]]

[[Category: Bartlam, M.]]

[[Category: Bartlam, M]]

[[Category: Chen, C.]]

[[Category: Chen, C]]

[[Category: Cong, L.]]

[[Category: Cong, L]]

[[Category: Fu, J.]]

[[Category: Fu, J]]

[[Category: Rao, Z.]]

[[Category: Rao, Z]]

[[Category: Tang, H.]]

[[Category: Tang, H]]

[[Category: Wei, L.]]

[[Category: Wei, L]]

[[Category: Xu, Y.]]

[[Category: Xu, Y]]

[[Category: Yang, A.]]

[[Category: Yang, A]]

[[Category: Globular like]]

[[Category: Host cytoplasm]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_3ld1|  PDB=3ld1  |  SCENE=  }}
+==Crystal Structure of IBV Nsp2a==
-===Crystal Structure of IBV Nsp2a===
+<StructureSection load='3ld1' size='340' side='right' caption='[[3ld1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[3ld1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LD1 FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/R1A_IBVM R1A_IBVM]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity).  The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).  The peptide p16 might be involved in the EGF signaling pathway (By similarity).  Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity).  Nsp9 is a ssRNA-binding protein (By similarity).
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">1a, 1ab ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ld1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ld1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ld1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ld1 PDBsum]</span></td></tr>
-==About this Structure==
+</table>
-[[3ld1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD1 OCA].
+__TOC__
+</StructureSection>
 [[Category: Viruses]]
-[[Category: Bartlam, M.]]
+[[Category: Bartlam, M]]
-[[Category: Chen, C.]]
+[[Category: Chen, C]]
-[[Category: Cong, L.]]
+[[Category: Cong, L]]
-[[Category: Fu, J.]]
+[[Category: Fu, J]]
-[[Category: Rao, Z.]]
+[[Category: Rao, Z]]
-[[Category: Tang, H.]]
+[[Category: Tang, H]]
-[[Category: Wei, L.]]
+[[Category: Wei, L]]
-[[Category: Xu, Y.]]
+[[Category: Xu, Y]]
-[[Category: Yang, A.]]
+[[Category: Yang, A]]
 [[Category: Globular like]]
 [[Category: Host cytoplasm]]