3p1a: Difference between revisions

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~~{{STRUCTURE_3p1a| PDB=3p1a | SCENE= }}~~

==Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)==

===Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[3p1a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1A OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P1A FirstGlance].

[[~~http://www.uniprot.org/uniprot/PMYT1_HUMAN PMYT1_HUMAN~~]] ~~Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins~~. ~~Mediates phosphorylation of CDK1 predominantly on~~ '~~Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on~~ '~~Tyr-15~~' ~~to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.<ref~~>~~PMID:9001210~~<~~/ref~~> <~~ref~~>~~PMID:10373560~~<~~/ref~~>

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">MYT1, PKMYT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

~~==About this Structure==~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </td></tr>

[[3p1a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1A OCA].

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p1a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p1a RCSB], [http://www.ebi.ac.uk/pdbsum/3p1a PDBsum]</td></tr>

</table>

==~~Reference~~==

__TOC__

<~~references group~~="~~xtra~~"/><~~references~~/>

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Arrowsmith, C H.]]

[[Category: Arrowsmith, C H]]

[[Category: Berridge, G.]]

[[Category: Berridge, G]]

[[Category: Bountra, C.]]

[[Category: Bountra, C]]

[[Category: Chaikuad, A.]]

[[Category: Chaikuad, A]]

[[Category: Cooper, C D.O.]]

[[Category: Cooper, C D.O]]

[[Category: Delft, F von.]]

[[Category: Delft, F von]]

[[Category: Edwards, A M.]]

[[Category: Edwards, A M]]

[[Category: Eswaran, J.]]

[[Category: Eswaran, J]]

[[Category: Fedorov, O.]]

[[Category: Fedorov, O]]

[[Category: Knapp, S.]]

[[Category: Knapp, S]]

[[Category: Kroeler, T.]]

[[Category: Kroeler, T]]

[[Category: Krojer, T.]]

[[Category: Krojer, T]]

[[Category: Muniz, J R.C.]]

[[Category: Muniz, J R.C]]

[[Category: Pike, A C.W.]]

[[Category: Pike, A C.W]]

[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]

[[Category: Structural genomic]]

[[Category: Vollmar, M.]]

[[Category: Vollmar, M]]

[[Category: Weigelt, J.]]

[[Category: Weigelt, J]]

[[Category: Membrane-associated protein kinase]]

[[Category: Protein kinase]]

[[Category: Sgc]]

~~[[Category: Structural genomic]]~~

~~[[Category: Structural genomics consortium]]~~

[[Category: Transferase]]

[[Category: Tyrosine- and threonine-specific kinase]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_3p1a|  PDB=3p1a  |  SCENE=  }}
+==Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)==
-===Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)===
+<StructureSection load='3p1a' size='340' side='right' caption='[[3p1a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[3p1a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P1A FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/PMYT1_HUMAN PMYT1_HUMAN]] Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.<ref>PMID:9001210</ref> <ref>PMID:10373560</ref>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MYT1, PKMYT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-==About this Structure==
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-[[3p1a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P1A OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p1a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p1a RCSB], [http://www.ebi.ac.uk/pdbsum/3p1a PDBsum]</span></td></tr>
+</table>
-==Reference==
+__TOC__
-<references group="xtra"/><references/>
+</StructureSection>
 [[Category: Homo sapiens]]
 [[Category: Non-specific serine/threonine protein kinase]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith, C H]]
-[[Category: Berridge, G.]]
+[[Category: Berridge, G]]
-[[Category: Bountra, C.]]
+[[Category: Bountra, C]]
-[[Category: Chaikuad, A.]]
+[[Category: Chaikuad, A]]
-[[Category: Cooper, C D.O.]]
+[[Category: Cooper, C D.O]]
-[[Category: Delft, F von.]]
+[[Category: Delft, F von]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards, A M]]
-[[Category: Eswaran, J.]]
+[[Category: Eswaran, J]]
-[[Category: Fedorov, O.]]
+[[Category: Fedorov, O]]
-[[Category: Knapp, S.]]
+[[Category: Knapp, S]]
-[[Category: Kroeler, T.]]
+[[Category: Kroeler, T]]
-[[Category: Krojer, T.]]
+[[Category: Krojer, T]]
-[[Category: Muniz, J R.C.]]
+[[Category: Muniz, J R.C]]
-[[Category: Pike, A C.W.]]
+[[Category: Pike, A C.W]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Structural genomic]]
-[[Category: Vollmar, M.]]
+[[Category: Vollmar, M]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt, J]]
 [[Category: Membrane-associated protein kinase]]
 [[Category: Protein kinase]]
 [[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
 [[Category: Transferase]]
 [[Category: Tyrosine- and threonine-specific kinase]]