1qs4: Difference between revisions

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[[Image:1qs4.gif|left|200px]]<br /><applet load="1qs4" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1qs4.gif|left|200px]]
caption="1qs4, resolution 2.10&Aring;" />
 
'''CORE DOMAIN OF HIV-1 INTEGRASE COMLEXED WITH MG++ AND 1-(5-CHLOROINDOL-3-YL)-3-HYDROXY-3-(2H-TETRAZOL-5-YL)-PROPENONE'''<br />
{{Structure
|PDB= 1qs4 |SIZE=350|CAPTION= <scene name='initialview01'>1qs4</scene>, resolution 2.10&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=100:1-(5-CHLOROINDOL-3-YL)-3-HYDROXY-3-(2H-TETRAZOL-5-YL)-PROPENONE'>100</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE=
}}
 
'''CORE DOMAIN OF HIV-1 INTEGRASE COMLEXED WITH MG++ AND 1-(5-CHLOROINDOL-3-YL)-3-HYDROXY-3-(2H-TETRAZOL-5-YL)-PROPENONE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1QS4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=100:'>100</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QS4 OCA].  
1QS4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QS4 OCA].  


==Reference==
==Reference==
Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design., Goldgur Y, Craigie R, Cohen GH, Fujiwara T, Yoshinaga T, Fujishita T, Sugimoto H, Endo T, Murai H, Davies DR, Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13040-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10557269 10557269]
Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design., Goldgur Y, Craigie R, Cohen GH, Fujiwara T, Yoshinaga T, Fujishita T, Sugimoto H, Endo T, Murai H, Davies DR, Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13040-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10557269 10557269]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: RNA-directed DNA polymerase]]
[[Category: RNA-directed DNA polymerase]]
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[[Category: integrase]]
[[Category: integrase]]


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