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{{STRUCTURE_3ntw|  PDB=3ntw  |  SCENE=  }}
==Structure of the MLLE domain of EDD in complex with a PAM2 peptide from Paip1==
===Structure of the MLLE domain of EDD in complex with a PAM2 peptide from Paip1===
<StructureSection load='3ntw' size='340' side='right' caption='[[3ntw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3ntw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NTW FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/UBR5_RAT UBR5_RAT]] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) for the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (By similarity). [[http://www.uniprot.org/uniprot/PAIP1_HUMAN PAIP1_HUMAN]] Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.<ref>PMID:9548260</ref> <ref>PMID:11051545</ref>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ubr5, Dd5, Edd, Edd1, Hyd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ntw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ntw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ntw RCSB], [http://www.ebi.ac.uk/pdbsum/3ntw PDBsum]</span></td></tr>
==About this Structure==
</table>
[[3ntw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTW OCA].  


==See Also==
==See Also==
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Gehring, K.]]
[[Category: Gehring, K]]
[[Category: Kozlov, G.]]
[[Category: Kozlov, G]]
[[Category: Mlle domain]]
[[Category: Mlle domain]]
[[Category: Pabc domain]]
[[Category: Pabc domain]]
[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]

Revision as of 07:19, 19 December 2014

Structure of the MLLE domain of EDD in complex with a PAM2 peptide from Paip1

3ntw, resolution 2.60Å

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