3q1c: Difference between revisions

Line 1:

~~{{STRUCTURE_3q1c~~| ~~PDB~~=3q1c | ~~SCENE~~= }}

==Structure of EspG Protein==

===~~Structure of EspG Protein~~===

~~{{ABSTRACT_PUBMED_21235237}}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3q1c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o127:h6 Escherichia coli o127:h6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q1C FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E2348C_3970, E2348_C_3970, espG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=168807 Escherichia coli O127:H6])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q1c RCSB], [http://www.ebi.ac.uk/pdbsum/3q1c PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Bacterial pathogens secrete effectors into their hosts that subvert host defenses and redirect host processes. EspG is a type three secretion effector with a disputed function that is found in enteropathogenic Escherichia coli. Here we show that EspG is structurally similar to VirA, a Shigella virulence factor; EspG has a large, conserved pocket on its surface; EspG binds directly to the amino-terminal inhibitory domain of human p21-activated kinase (PAK); and mutations to conserved residues in the surface pocket disrupt the interaction with PAK.

~~==About this Structure==~~

Structural and Functional Studies Indicate That the EPEC Effector, EspG, Directly Binds p21-Activated Kinase.,Germane KL, Spiller BW Biochemistry. 2011 Feb 15;50(6):917-9. Epub 2011 Jan 24. PMID:21235237<ref>PMID:21235237</ref>

~~[[3q1c]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_o127:h6 Escherichia coli o127~~:~~h6]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1C OCA].~~

==~~Reference~~==

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~<ref group="xtra">PMID:021235237</ref>~~<references ~~group="xtra"~~/><~~references~~/>

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Escherichia coli o127:h6]]

[[Category: Germane, K L.]]

[[Category: Germane, K L]]

[[Category: Spiller, B W.]]

[[Category: Spiller, B W]]

[[Category: P21 activated kinase]]

[[Category: Pak recruitment and activation]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-{{STRUCTURE_3q1c|  PDB=3q1c  |  SCENE=  }}
+==Structure of EspG Protein==
-===Structure of EspG Protein===
+<StructureSection load='3q1c' size='340' side='right' caption='[[3q1c]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-{{ABSTRACT_PUBMED_21235237}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3q1c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o127:h6 Escherichia coli o127:h6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q1C FirstGlance]. <br>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E2348C_3970, E2348_C_3970, espG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=168807 Escherichia coli O127:H6])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q1c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q1c RCSB], [http://www.ebi.ac.uk/pdbsum/3q1c PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Bacterial pathogens secrete effectors into their hosts that subvert host defenses and redirect host processes. EspG is a type three secretion effector with a disputed function that is found in enteropathogenic Escherichia coli. Here we show that EspG is structurally similar to VirA, a Shigella virulence factor; EspG has a large, conserved pocket on its surface; EspG binds directly to the amino-terminal inhibitory domain of human p21-activated kinase (PAK); and mutations to conserved residues in the surface pocket disrupt the interaction with PAK.
-==About this Structure==
+Structural and Functional Studies Indicate That the EPEC Effector, EspG, Directly Binds p21-Activated Kinase.,Germane KL, Spiller BW Biochemistry. 2011 Feb 15;50(6):917-9. Epub 2011 Jan 24. PMID:21235237<ref>PMID:21235237</ref>
-[[3q1c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o127:h6 Escherichia coli o127:h6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q1C OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:021235237</ref><references group="xtra"/><references/>
+</div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Escherichia coli o127:h6]]
-[[Category: Germane, K L.]]
+[[Category: Germane, K L]]
-[[Category: Spiller, B W.]]
+[[Category: Spiller, B W]]
 [[Category: P21 activated kinase]]
 [[Category: Pak recruitment and activation]]