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{{STRUCTURE_3psp|  PDB=3psp  |  SCENE=  }}
==Crystal structure of PUL and PFU domain==
===Crystal structure of PUL and PFU domain===
<StructureSection load='3psp' size='340' side='right' caption='[[3psp]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3psp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PSP FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/DOA1_YEAST DOA1_YEAST]] Participates in the regulation of the ubiquitin conjugation pathway involving CDC48 by hindering multiubiquitination of substrates at the CDC48 chaperone. May act by preventing the interaction between CDC48 and the E4 enzyme UFD2, leading to prevent multiubiquitination of substrates and subsequent degradation. Essential for maintaining cellular ubiquitin levels.<ref>PMID:15096053</ref> <ref>PMID:8890162</ref>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pst|3pst]]</td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOA1, UFD3, ZZZ4, YKL213C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3psp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3psp RCSB], [http://www.ebi.ac.uk/pdbsum/3psp PDBsum]</span></td></tr>
[[3psp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSP OCA].  
</table>
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Liu, Y.]]
[[Category: Liu, Y]]
[[Category: Sun, J.]]
[[Category: Sun, J]]
[[Category: Cdc48 ubiquitin]]
[[Category: Cdc48 ubiquitin]]
[[Category: Maintain the ubiquitin level]]
[[Category: Maintain the ubiquitin level]]
[[Category: Nuclear protein]]
[[Category: Nuclear protein]]
[[Category: Protein degradation]]
[[Category: Protein degradation]]

Revision as of 10:09, 19 December 2014

Crystal structure of PUL and PFU domain

3psp, resolution 2.42Å

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