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{{STRUCTURE_3pyc|  PDB=3pyc  |  SCENE=  }}
==Crystal structure of human SMURF1 C2 domain==
===Crystal structure of human SMURF1 C2 domain===
<StructureSection load='3pyc' size='340' side='right' caption='[[3pyc]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
{{ABSTRACT_PUBMED_021402695}}
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3pyc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PYC FirstGlance]. <br>
==Function==
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[http://www.uniprot.org/uniprot/SMUF1_HUMAN SMUF1_HUMAN]] E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.<ref>PMID:10458166</ref> <ref>PMID:19937093</ref> <ref>PMID:21402695</ref>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMURF1, KIAA1625 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pyc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pyc RCSB], [http://www.ebi.ac.uk/pdbsum/3pyc PDBsum]</span></td></tr>
==About this Structure==
</table>
[[3pyc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYC OCA].  


==See Also==
==See Also==
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021402695</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Li, P.]]
[[Category: Li, P]]
[[Category: Li, X.]]
[[Category: Li, X]]
[[Category: Lipid binding protein]]
[[Category: Lipid binding protein]]
[[Category: Membrane associate]]
[[Category: Membrane associate]]
[[Category: Phospholipid binding]]
[[Category: Phospholipid binding]]

Revision as of 10:17, 19 December 2014

Crystal structure of human SMURF1 C2 domain

3pyc, resolution 1.96Å

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