3qf8: Difference between revisions

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~~{{STRUCTURE_3qf8| PDB=3qf8 | SCENE= }}~~

==X-ray crystal structure of the ruthenium complex [Ru(tap)2(dppz)]2+ bound to d(TCGGCGCCGA) at medium resolution==

===X-ray crystal structure of the ruthenium complex [Ru(tap)2(dppz)]2+ bound to d(TCGGCGCCGA) at medium resolution===

~~{{ABSTRACT_PUBMED_21969542}}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3qf8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QF8 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=RKL:RU(TAP)2(DPPZ)+COMPLEX'>RKL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qf8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qf8 RCSB], [http://www.ebi.ac.uk/pdbsum/3qf8 PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

We describe a crystal structure, at atomic resolution (1.1 A, 100 K), of a ruthenium polypyridyl complex bound to duplex DNA, in which one ligand acts as a wedge in the minor groove, resulting in the 51 degrees kinking of the double helix. The complex cation Lambda-[Ru(1,4,5,8-tetraazaphenanthrene)(2)(dipyridophenazine)](2+) crystallizes in a 11 ratio with the oligonucleotide d(TCGGCGCCGA) in the presence of barium ions. Each complex binds to one duplex by intercalation of the dipyridophenazine ligand and also by semiintercalation of one of the orthogonal tetraazaphenanthrene ligands into a second symmetrically equivalent duplex. The result is noncovalent cross-linking and marked kinking of DNA.

~~==About this~~ Structure==

Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand.,Hall JP, O'Sullivan K, Naseer A, Smith JA, Kelly JM, Cardin CJ Proc Natl Acad Sci U S A. 2011 Oct 3. PMID:21969542<ref>PMID:21969542</ref>

~~[[3qf8]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il/oca-bin~~/~~ocashort?id=3QF8 OCA].~~

==~~Reference~~==

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~<ref group="xtra">PMID:021969542</ref>~~<references ~~group="xtra"~~/><~~references~~/>

</div>

[[Category: Cardin, C J.]]

== References ==

[[Category: Hall, J P.]]

__TOC__

</StructureSection>

[[Category: Cardin, C J]]

[[Category: Hall, J P]]

[[Category: B-dna]]

[[Category: Dna]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_3qf8|  PDB=3qf8  |  SCENE=  }}
+==X-ray crystal structure of the ruthenium complex [Ru(tap)2(dppz)]2+ bound to d(TCGGCGCCGA) at medium resolution==
-===X-ray crystal structure of the ruthenium complex [Ru(tap)2(dppz)]2+ bound to d(TCGGCGCCGA) at medium resolution===
+<StructureSection load='3qf8' size='340' side='right' caption='[[3qf8]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
-{{ABSTRACT_PUBMED_21969542}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3qf8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QF8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QF8 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=RKL:RU(TAP)2(DPPZ)+COMPLEX'>RKL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qf8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qf8 RCSB], [http://www.ebi.ac.uk/pdbsum/3qf8 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We describe a crystal structure, at atomic resolution (1.1 A, 100 K), of a ruthenium polypyridyl complex bound to duplex DNA, in which one ligand acts as a wedge in the minor groove, resulting in the 51 degrees kinking of the double helix. The complex cation Lambda-[Ru(1,4,5,8-tetraazaphenanthrene)(2)(dipyridophenazine)](2+) crystallizes in a 11 ratio with the oligonucleotide d(TCGGCGCCGA) in the presence of barium ions. Each complex binds to one duplex by intercalation of the dipyridophenazine ligand and also by semiintercalation of one of the orthogonal tetraazaphenanthrene ligands into a second symmetrically equivalent duplex. The result is noncovalent cross-linking and marked kinking of DNA.
-==About this Structure==
+Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand.,Hall JP, O'Sullivan K, Naseer A, Smith JA, Kelly JM, Cardin CJ Proc Natl Acad Sci U S A. 2011 Oct 3. PMID:21969542<ref>PMID:21969542</ref>
-[[3qf8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QF8 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:021969542</ref><references group="xtra"/><references/>
+</div>
-[[Category: Cardin, C J.]]
+== References ==
-[[Category: Hall, J P.]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cardin, C J]]
+[[Category: Hall, J P]]
 [[Category: B-dna]]
 [[Category: Dna]]