3rgx: Difference between revisions
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==Structural insight into brassinosteroid perception by BRI1== | |||
=== | <StructureSection load='3rgx' size='340' side='right' caption='[[3rgx]], [[Resolution|resolution]] 2.47Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3rgx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RGX FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rgz|3rgz]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRI1, At4g39400, F23K16.30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rgx RCSB], [http://www.ebi.ac.uk/pdbsum/3rgx PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Brassinosteroids are essential phytohormones that have crucial roles in plant growth and development. Perception of brassinosteroids requires an active complex of BRASSINOSTEROID-INSENSITIVE 1 (BRI1) and BRI1-ASSOCIATED KINASE 1 (BAK1). Recognized by the extracellular leucine-rich repeat (LRR) domain of BRI1, brassinosteroids induce a phosphorylation-mediated cascade to regulate gene expression. Here we present the crystal structures of BRI1(LRR) in free and brassinolide-bound forms. BRI1(LRR) exists as a monomer in crystals and solution independent of brassinolide. It comprises a helical solenoid structure that accommodates a separate insertion domain at its concave surface. Sandwiched between them, brassinolide binds to a hydrophobicity-dominating surface groove on BRI1(LRR). Brassinolide recognition by BRI1(LRR) is through an induced-fit mechanism involving stabilization of two interdomain loops that creates a pronounced non-polar surface groove for the hormone binding. Together, our results define the molecular mechanisms by which BRI1 recognizes brassinosteroids and provide insight into brassinosteroid-induced BRI1 activation. | |||
Structural insight into brassinosteroid perception by BRI1.,She J, Han Z, Kim TW, Wang J, Cheng W, Chang J, Shi S, Wang J, Yang M, Wang ZY, Chai J Nature. 2011 Jun 12;474(7352):472-6. doi: 10.1038/nature10178. PMID:21666666<ref>PMID:21666666</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arabidopsis thaliana]] | [[Category: Arabidopsis thaliana]] | ||
[[Category: Chai, J | [[Category: Chai, J]] | ||
[[Category: Cheng, W | [[Category: Cheng, W]] | ||
[[Category: Han, Z | [[Category: Han, Z]] | ||
[[Category: She, J | [[Category: She, J]] | ||
[[Category: Wang, J | [[Category: Wang, J]] | ||
[[Category: Brassinosteroid]] | [[Category: Brassinosteroid]] | ||
[[Category: Leucine-rich repeat]] | [[Category: Leucine-rich repeat]] | ||
Revision as of 10:35, 19 December 2014
Structural insight into brassinosteroid perception by BRI1
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