3rmu: Difference between revisions
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==Crystal structure of human Methylmalonyl-CoA epimerase, MCEE== | |||
=== | <StructureSection load='3rmu' size='340' side='right' caption='[[3rmu]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | |||
==Disease== | <table><tr><td colspan='2'>[[3rmu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RMU FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCEE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_epimerase Methylmalonyl-CoA epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.99.1 5.1.99.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rmu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rmu RCSB], [http://www.ebi.ac.uk/pdbsum/3rmu PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/MCEE_HUMAN MCEE_HUMAN]] Vitamin B12-unresponsive methylmalonic acidemia. Methylmalonyl-CoA epimerase deficiency (MCEED) [MIM:[http://omim.org/entry/251120 251120]]: Autosomal recessive inborn error of amino acid metabolism, involving valine, threonine, isoleucine and methionine. This organic aciduria may present in the neonatal period with life-threatening metabolic acidosis, hyperammonemia, feeding difficulties, pancytopenia and coma. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16752391</ref> | [[http://www.uniprot.org/uniprot/MCEE_HUMAN MCEE_HUMAN]] Vitamin B12-unresponsive methylmalonic acidemia. Methylmalonyl-CoA epimerase deficiency (MCEED) [MIM:[http://omim.org/entry/251120 251120]]: Autosomal recessive inborn error of amino acid metabolism, involving valine, threonine, isoleucine and methionine. This organic aciduria may present in the neonatal period with life-threatening metabolic acidosis, hyperammonemia, feeding difficulties, pancytopenia and coma. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16752391</ref> | ||
== Function == | |||
== | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
<references | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Methylmalonyl-CoA epimerase]] | [[Category: Methylmalonyl-CoA epimerase]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Chaikuad, A | [[Category: Chaikuad, A]] | ||
[[Category: Delft, F von | [[Category: Delft, F von]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Froese, D S | [[Category: Froese, D S]] | ||
[[Category: Krysztofinska, E | [[Category: Krysztofinska, E]] | ||
[[Category: Muniz, J R.C | [[Category: Muniz, J R.C]] | ||
[[Category: Oppermann, U | [[Category: Oppermann, U]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Vollmar, M | [[Category: Vollmar, M]] | ||
[[Category: Weigelt, J | [[Category: Weigelt, J]] | ||
[[Category: Yue, W W | [[Category: Yue, W W]] | ||
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
[[Category: Mitochondria]] | [[Category: Mitochondria]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Vitamin b12]] | [[Category: Vitamin b12]] | ||
Revision as of 10:56, 19 December 2014
Crystal structure of human Methylmalonyl-CoA epimerase, MCEE
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