3qah: Difference between revisions

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{{STRUCTURE_3qah|  PDB=3qah  |  SCENE=  }}
==Crystal structure of apo-form human MOF catalytic domain==
===Crystal structure of apo-form human MOF catalytic domain===
<StructureSection load='3qah' size='340' side='right' caption='[[3qah]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3qah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QAH FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/KAT8_HUMAN KAT8_HUMAN]] Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex.<ref>PMID:12397079</ref> <ref>PMID:15923642</ref> <ref>PMID:20018852</ref> 
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
==About this Structure==
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MOF, MYST1, PP7073 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
[[3qah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QAH OCA].  
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qah RCSB], [http://www.ebi.ac.uk/pdbsum/3qah PDBsum]</span></td></tr>
==Reference==
</table>
<ref group="xtra">PMID:021691301</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Histone acetyltransferase]]
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ding, J.]]
[[Category: Ding, J]]
[[Category: Sun, B.]]
[[Category: Sun, B]]
[[Category: Tang, Q.]]
[[Category: Tang, Q]]
[[Category: Zhong, C.]]
[[Category: Zhong, C]]
[[Category: Autoacetylation]]
[[Category: Autoacetylation]]
[[Category: Dosage compensation]]
[[Category: Dosage compensation]]
[[Category: H4k16 acetylation]]
[[Category: H4k16 acetylation]]
[[Category: Histone acetyltransferase]]
[[Category: Human mof]]
[[Category: Human mof]]
[[Category: Myst]]
[[Category: Myst]]
[[Category: Transferase]]
[[Category: Transferase]]
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