3qik: Difference between revisions

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~~{{STRUCTURE_3qik| PDB=3qik | SCENE= }}~~

==Crystal structure of the first PDZ domain of PREX1==

===Crystal structure of the first PDZ domain of PREX1===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[3qik]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIK OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QIK FirstGlance].

[[~~http://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN~~]] ~~Functions as a RAC guanine nucleotide exchange factor (GEF)~~, which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">PREX1, KIAA1415 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

==~~About this Structure~~==

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qik OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qik RCSB], [http://www.ebi.ac.uk/pdbsum/3qik PDBsum]</td></tr>

[[3qik]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIK OCA].

</table>

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Arrowsmith, C H.]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C.]]

[[Category: Bountra, C]]

[[Category: Edwards, A M.]]

[[Category: Edwards, A M]]

[[Category: Li, Y.]]

[[Category: Li, Y]]

[[Category: Park, H.]]

[[Category: Park, H]]

[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]

[[Category: Structural genomic]]

[[Category: Shen, L.]]

[[Category: Shen, L]]

[[Category: Tempel, W.]]

[[Category: Tempel, W]]

[[Category: Tong, Y.]]

[[Category: Tong, Y]]

[[Category: Weigelt, J.]]

[[Category: Weigelt, J]]

[[Category: Hydrolase regulator]]

[[Category: Pdz domain]]

[[Category: Sgc]]

~~[[Category: Structural genomics consortium]]~~

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_3qik|  PDB=3qik  |  SCENE=  }}
+==Crystal structure of the first PDZ domain of PREX1==
-===Crystal structure of the first PDZ domain of PREX1===
+<StructureSection load='3qik' size='340' side='right' caption='[[3qik]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[3qik]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QIK FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN]] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PREX1, KIAA1415 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qik OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qik RCSB], [http://www.ebi.ac.uk/pdbsum/3qik PDBsum]</span></td></tr>
-[[3qik]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIK OCA].
+</table>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith, C H]]
-[[Category: Bountra, C.]]
+[[Category: Bountra, C]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards, A M]]
-[[Category: Li, Y.]]
+[[Category: Li, Y]]
-[[Category: Park, H.]]
+[[Category: Park, H]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Structural genomic]]
-[[Category: Shen, L.]]
+[[Category: Shen, L]]
-[[Category: Tempel, W.]]
+[[Category: Tempel, W]]
-[[Category: Tong, Y.]]
+[[Category: Tong, Y]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt, J]]
 [[Category: Hydrolase regulator]]
 [[Category: Pdz domain]]
 [[Category: Sgc]]
-[[Category: Structural genomics consortium]]