3s9b: Difference between revisions
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==Russell's viper venom serine proteinase, RVV-V (open-form)== | |||
<StructureSection load='3s9b' size='340' side='right' caption='[[3s9b]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3s9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_siamensis Daboia russellii siamensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S9B FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s9a|3s9a]], [[3s9c|3s9c]], [[3sbk|3sbk]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Snake_venom_factor_V_activator Snake venom factor V activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.95 3.4.21.95] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s9b RCSB], [http://www.ebi.ac.uk/pdbsum/3s9b PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Russell's viper venom factor V (FV) activator (RVV-V) is a thrombin-like proteinase that specifically cleaves the Arg1545-Ser1546 bond of FV. Here we present the crystal structure of RVV-V in complex with the FV14 peptide (residues 1533-1546 of human FV) determined at 1.8A resolution. The structure reveals multiple interactions between RVV-V and the seven residues, Ile1539 (P(7))-Arg1545 (P(1)), of the cleaved substrate. Comparison with substrate-free structures reveals conformational changes of the RVV-V loops upon substrate binding, suggesting that the multiple interactions are mediated by an induced-fit mechanism. The results provide an explanation for the narrow specificity of RVV-V. | |||
Structural basis of coagulation factor V recognition for cleavage by RVV-V.,Nakayama D, Ben Ammar Y, Miyata T, Takeda S FEBS Lett. 2011 Aug 23. PMID:21871889<ref>PMID:21871889</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== | ==See Also== | ||
*[[Proteinase|Proteinase]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Daboia russellii siamensis]] | [[Category: Daboia russellii siamensis]] | ||
[[Category: Snake venom factor V activator]] | [[Category: Snake venom factor V activator]] | ||
[[Category: Ammar, Y Ben | [[Category: Ammar, Y Ben]] | ||
[[Category: Nakayama, D | [[Category: Nakayama, D]] | ||
[[Category: Takeda, S | [[Category: Takeda, S]] | ||
[[Category: Double six-stranded beta-barrel]] | [[Category: Double six-stranded beta-barrel]] | ||
[[Category: Glycosylation]] | [[Category: Glycosylation]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Serine proteinase]] | [[Category: Serine proteinase]] | ||
Revision as of 06:28, 21 December 2014
Russell's viper venom serine proteinase, RVV-V (open-form)
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