1r6g: Difference between revisions

Line 1:

[[Image:1r6g.gif|left|200px]]~~<br /><applet load~~="1r6g~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1r6g.gif|left|200px]]

~~caption="~~1r6g, resolution 3.00Å" />

'''Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound'''~~<br />~~

{{Structure

|PDB= 1r6g |SIZE=350|CAPTION= <scene name='initialview01'>1r6g</scene>, resolution 3.00Å

|SITE=

|LIGAND= <scene name='pdbligand=442:2-[3,5-DIBROMO-4-(4-HYDROXY-3-{HYDROXY[(2-PHENYLETHYL)AMINO]METHYL}PHENOXY)PHENYL]ETHANE-1,1-DIOL'>442</scene>

|ACTIVITY=

|GENE= THRB, NR1A2, ERBA2, THR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])

}}

'''Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound'''

==Overview==

Line 10:

Line 19:

==About this Structure==

1R6G is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~] with <scene name='pdbligand=442:'>442</scene> as [http://en.wikipedia.org/wiki/ligand ligand~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6G OCA].

1R6G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6G OCA].

==Reference==

Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta., Hangeland JJ, Doweyko AM, Dejneka T, Friends TJ, Devasthale P, Mellstrom K, Sandberg J, Grynfarb M, Sack JS, Einspahr H, Farnegardh M, Husman B, Ljunggren J, Koehler K, Sheppard C, Malm J, Ryono DE, Bioorg Med Chem Lett. 2004 Jul 5;14(13):3549-53. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~15177471 15177471]

Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta., Hangeland JJ, Doweyko AM, Dejneka T, Friends TJ, Devasthale P, Mellstrom K, Sandberg J, Grynfarb M, Sack JS, Einspahr H, Farnegardh M, Husman B, Ljunggren J, Koehler K, Sheppard C, Malm J, Ryono DE, Bioorg Med Chem Lett. 2004 Jul 5;14(13):3549-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15177471 15177471]

[[Category: Homo sapiens]]

[[Category: Single protein]]

Line 36:

Line 45:

[[Category: alpha helical]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 14~~:47:34 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:47:28 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1r6g.gif|left|200px]]<br /><applet load="1r6g" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1r6g.gif|left|200px]]
-caption="1r6g, resolution 3.00&Aring;" />
-'''Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound'''<br />
+ {{Structure
+|PDB= 1r6g |SIZE=350|CAPTION= <scene name='initialview01'>1r6g</scene>, resolution 3.00&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=442:2-[3,5-DIBROMO-4-(4-HYDROXY-3-{HYDROXY[(2-PHENYLETHYL)AMINO]METHYL}PHENOXY)PHENYL]ETHANE-1,1-DIOL'>442</scene>
+|ACTIVITY=
+|GENE= THRB, NR1A2, ERBA2, THR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound'''
 ==Overview==
@@ Line 10: / Line 19: @@
 ==About this Structure==
-R6G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=442:'>442</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6G OCA].
+R6G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6G OCA].
 ==Reference==
-Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta., Hangeland JJ, Doweyko AM, Dejneka T, Friends TJ, Devasthale P, Mellstrom K, Sandberg J, Grynfarb M, Sack JS, Einspahr H, Farnegardh M, Husman B, Ljunggren J, Koehler K, Sheppard C, Malm J, Ryono DE, Bioorg Med Chem Lett. 2004 Jul 5;14(13):3549-53. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15177471 15177471]
+Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta., Hangeland JJ, Doweyko AM, Dejneka T, Friends TJ, Devasthale P, Mellstrom K, Sandberg J, Grynfarb M, Sack JS, Einspahr H, Farnegardh M, Husman B, Ljunggren J, Koehler K, Sheppard C, Malm J, Ryono DE, Bioorg Med Chem Lett. 2004 Jul 5;14(13):3549-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15177471 15177471]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 36: / Line 45: @@
 [[Category: alpha helical]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:47:34 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:47:28 2008''