3t0m: Difference between revisions

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{{STRUCTURE_3t0m|  PDB=3t0m  |  SCENE=  }}
==Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening==
===Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening===
<StructureSection load='3t0m' size='340' side='right' caption='[[3t0m]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
{{ABSTRACT_PUBMED_23939230}}
== Structural highlights ==
<table><tr><td colspan='2'>[[3t0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T0M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CT:(2-{2-[(2,5-DIMETHOXYPHENYL)AMINO]-2-OXOETHOXY}PHENYL)PHOSPHONIC+ACID'>2CT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lw1|3lw1]], [[3mhr|3mhr]], [[3t0l|3t0l]], [[3u9x|3u9x]], [[4dhm|4dhm]], [[4dhn|4dhn]], [[4dho|4dho]], [[4dhp|4dhp]], [[4dhq|4dhq]], [[4dhr|4dhr]], [[4dhs|4dhs]], [[4dht|4dht]], [[4dhu|4dhu]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HME1, SFN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t0m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t0m RCSB], [http://www.ebi.ac.uk/pdbsum/3t0m PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report first non-covalent and exclusively extracellular inhibitors of 14-3-3 protein-protein interactions identified by virtual screening. Optimization by crystal structure analysis and in vitro binding assays yielded compounds capable of disrupting the interaction of 14-3-3sigma with aminopeptidase N in a cellular assay.


==Function==
Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.,Thiel P, Roglin L, Meissner N, Hennig S, Kohlbacher O, Ottmann C Chem Commun (Camb). 2013 Aug 27;49(76):8468-70. doi: 10.1039/c3cc44612c. PMID:23939230<ref>PMID:23939230</ref>
[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.  


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[3t0m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T0M OCA].
</div>


==Reference==
==See Also==
<ref group="xtra">PMID:023939230</ref><references group="xtra"/><references/>
*[[14-3-3 protein|14-3-3 protein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ottmann, C.]]
[[Category: Ottmann, C]]
[[Category: Thiel, P.]]
[[Category: Thiel, P]]
[[Category: Adapter protein]]
[[Category: Adapter protein]]
[[Category: Helical protein]]
[[Category: Helical protein]]
[[Category: Protein binding-inhibitor complex]]
[[Category: Protein binding-inhibitor complex]]
[[Category: Protein-protein interaction]]
[[Category: Protein-protein interaction]]
Retrieved from "https://proteopedia.org/3t0m"