3ulb: Difference between revisions

Line 1:

~~{{STRUCTURE_3ulb| PDB=3ulb | SCENE= }}~~

==Crystal structure of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1, a TORC2 subunit, in the P212121 crystal form==

===Crystal structure of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1, a TORC2 subunit, in the P212121 crystal form===

~~{{ABSTRACT_PUBMED_22505404}}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3ulb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ULB FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ulc|3ulc]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AVO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ulb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ulb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ulb RCSB], [http://www.ebi.ac.uk/pdbsum/3ulb PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

In eukaryotes, multiprotein complexes termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2) function as major regulators of cell growth, metabolism and ageing. The C-terminal domain of the Saccharomyces cerevisiae TORC2 component Avo1 is required for plasma-membrane localization of TORC2 and is essential for yeast viability. X-ray crystal structures of the C-terminal domain of Avo1 and of its human orthologue Sin1 have been determined. The structures show that the C-termini of Avo1 and Sin1 both have the pleckstrin homology (PH) domain fold. Comparison with known PH-domain structures suggests a putative binding site for phosphoinositides.

~~==Function==~~

Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2.,Pan D, Matsuura Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):386-92., Epub 2012 Mar 27. PMID:22505404<ref>PMID:22505404</ref>

~~[[http://www.uniprot.org/uniprot/AVO1_YEAST AVO1_YEAST]] Component~~ of ~~TORC2~~, ~~which regulates cell cycle-dependent polarization~~ of ~~the actin~~-~~cytoskeleton and cell wall integrity~~. ~~TORC2 controls polarity of the actin cytoskeleton~~, ~~which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1~~/~~PKC1/MAPK cell integrity pathway.~~

~~==About this Structure==~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~[[3ulb]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3ULB OCA].~~

</div>

== References ==

~~==See Also==~~

*[[Variable lymphocyte receptor|Variable lymphocyte receptor]]

__TOC__

</StructureSection>

==~~Reference~~==

~~<ref group="xtra">PMID:022505404</ref>~~<references ~~group="xtra"~~/><~~references~~/>

[[Category: Saccharomyces cerevisiae s288c]]

[[Category: Matsuura, Y.]]

[[Category: Matsuura, Y]]

[[Category: Pan, D.]]

[[Category: Pan, D]]

[[Category: Membrane localization]]

[[Category: Membrane protein]]

[[Category: Ph domain]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_3ulb|  PDB=3ulb  |  SCENE=  }}
+==Crystal structure of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1, a TORC2 subunit, in the P212121 crystal form==
-===Crystal structure of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1, a TORC2 subunit, in the P212121 crystal form===
+<StructureSection load='3ulb' size='340' side='right' caption='[[3ulb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-{{ABSTRACT_PUBMED_22505404}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ulb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ULB FirstGlance]. <br>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ulc|3ulc]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AVO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ulb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ulb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ulb RCSB], [http://www.ebi.ac.uk/pdbsum/3ulb PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In eukaryotes, multiprotein complexes termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2) function as major regulators of cell growth, metabolism and ageing. The C-terminal domain of the Saccharomyces cerevisiae TORC2 component Avo1 is required for plasma-membrane localization of TORC2 and is essential for yeast viability. X-ray crystal structures of the C-terminal domain of Avo1 and of its human orthologue Sin1 have been determined. The structures show that the C-termini of Avo1 and Sin1 both have the pleckstrin homology (PH) domain fold. Comparison with known PH-domain structures suggests a putative binding site for phosphoinositides.
-==Function==
+Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2.,Pan D, Matsuura Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):386-92., Epub 2012 Mar 27. PMID:22505404<ref>PMID:22505404</ref>
-[[http://www.uniprot.org/uniprot/AVO1_YEAST AVO1_YEAST]] Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
-==About this Structure==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[3ulb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULB OCA].
+</div>
+== References ==
-==See Also==
+<references/>
-*[[Variable lymphocyte receptor|Variable lymphocyte receptor]]
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:022505404</ref><references group="xtra"/><references/>
 [[Category: Saccharomyces cerevisiae s288c]]
-[[Category: Matsuura, Y.]]
+[[Category: Matsuura, Y]]
-[[Category: Pan, D.]]
+[[Category: Pan, D]]
 [[Category: Membrane localization]]
 [[Category: Membrane protein]]
 [[Category: Ph domain]]