1ra5: Difference between revisions

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[[Image:1ra5.jpg|left|200px]]<br /><applet load="1ra5" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ra5.jpg|left|200px]]
caption="1ra5, resolution 1.40&Aring;" />
 
'''Bacterial cytosine deaminase D314A mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine.'''<br />
{{Structure
|PDB= 1ra5 |SIZE=350|CAPTION= <scene name='initialview01'>1ra5</scene>, resolution 1.40&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FPY:(4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE'>FPY</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Cytosine_deaminase Cytosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.1 3.5.4.1]
|GENE= CODA, B0337 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''Bacterial cytosine deaminase D314A mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine.'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1RA5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=FE:'>FE</scene>, <scene name='pdbligand=FPY:'>FPY</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cytosine_deaminase Cytosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.1 3.5.4.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RA5 OCA].  
1RA5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RA5 OCA].  


==Reference==
==Reference==
Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy., Mahan SD, Ireton GC, Knoeber C, Stoddard BL, Black ME, Protein Eng Des Sel. 2004 Aug;17(8):625-33. Epub 2004 Sep 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15381761 15381761]
Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy., Mahan SD, Ireton GC, Knoeber C, Stoddard BL, Black ME, Protein Eng Des Sel. 2004 Aug;17(8):625-33. Epub 2004 Sep 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15381761 15381761]
[[Category: Cytosine deaminase]]
[[Category: Cytosine deaminase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: hexamer]]
[[Category: hexamer]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:48:40 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:48:52 2008''
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