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{{STRUCTURE_3vol|  PDB=3vol  |  SCENE=  }}
==X-ray Crystal Structure of PAS-HAMP Aer2 in the CN-bound Form==
===X-ray Crystal Structure of PAS-HAMP Aer2 in the CN-bound Form===
<StructureSection load='3vol' size='340' side='right' caption='[[3vol]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
{{ABSTRACT_PUBMED_22622145}}
== Structural highlights ==
<table><tr><td colspan='2'>[[3vol]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VOL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aer2, PA0176 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 Pseudomonas aeruginosa PAO1])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vol OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vol RCSB], [http://www.ebi.ac.uk/pdbsum/3vol PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of a truncated Aer2, a signal transducer protein from Pseudomonas aeruginosa, consisting of the heme-containing PAS and di-HAMP domains revealed that a distal tryptophan residue (Trp283) plays an important role in stabilizing the heme-bound O(2) and intra-molecular signal transduction upon O(2) binding.


==About this Structure==
Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa.,Sawai H, Sugimoto H, Shiro Y, Ishikawa H, Mizutani Y, Aono S Chem Commun (Camb). 2012 Jul 4;48(52):6523-5. doi: 10.1039/c2cc32549g. Epub 2012 , May 23. PMID:22622145<ref>PMID:22622145</ref>
[[3vol]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VOL OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<ref group="xtra">PMID:022622145</ref><references group="xtra"/><references/>
</div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Pseudomonas aeruginosa pao1]]
[[Category: Pseudomonas aeruginosa pao1]]
[[Category: Aono, S.]]
[[Category: Aono, S]]
[[Category: Sawai, H.]]
[[Category: Sawai, H]]
[[Category: Shiro, Y.]]
[[Category: Shiro, Y]]
[[Category: Sugimoto, H.]]
[[Category: Sugimoto, H]]
[[Category: Cn-bound]]
[[Category: Cn-bound]]
[[Category: Cyanomet]]
[[Category: Cyanomet]]
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