3u80: Difference between revisions
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==1.60 Angstrom Resolution Crystal Structure of a 3-Dehydroquinate Dehydratase-like Protein from Bifidobacterium longum== | |||
<StructureSection load='3u80' size='340' side='right' caption='[[3u80]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3u80]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bifidobacterium_longum_subsp._longum_jdm301 Bifidobacterium longum subsp. longum jdm301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U80 FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BLJ_0876 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759350 Bifidobacterium longum subsp. longum JDM301])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u80 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u80 RCSB], [http://www.ebi.ac.uk/pdbsum/3u80 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Dehydroquinate dehydratase (DHQD) catalyzes the third step in the biosynthetic shikimate pathway. Here we identify a Bifidobacterium longum protein with high sequence homology to type II DHQDs but no detectable DHQD activity under standard assay conditions. A crystal structure reveals that the B. longum protein adopts a DHQD-like tertiary structure but a distinct quaternary state. Apparently forming a dimer, the B. longum protein lacks the active site aspartic acid contributed from a neighboring protomer in the type II DHQD dodecamer. Relating to the absence of protein-protein interactions established in the type II DHQD dodecameric assembly, substantial conformational changes distinguish the would-be active site of the B. longum protein. As B. longum possess no other genes with homology to known DHQDs, these findings imply a unique DHQD activity within B. longum. | |||
Crystal structure of a type II dehydroquinate dehydratase-like protein from Bifidobacterium longum.,Light SH, Krishna SN, Bergan RC, Lavie A, Anderson WF J Struct Funct Genomics. 2013 Mar;14(1):25-30. doi: 10.1007/s10969-013-9149-7., Epub 2013 Mar 29. PMID:23539270<ref>PMID:23539270</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
[[ | </div> | ||
==See Also== | |||
*[[Dehydroquinase|Dehydroquinase]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bifidobacterium longum subsp. longum jdm301]] | [[Category: Bifidobacterium longum subsp. longum jdm301]] | ||
[[Category: Anderson, W F | [[Category: Anderson, W F]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Lavie, A | [[Category: Lavie, A]] | ||
[[Category: Light, S H | [[Category: Light, S H]] | ||
[[Category: Minasov, G | [[Category: Minasov, G]] | ||
[[Category: Papazisi, L | [[Category: Papazisi, L]] | ||
[[Category: Shuvalova, L | [[Category: Shuvalova, L]] | ||
[[Category: Csgid]] | [[Category: Csgid]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
Revision as of 07:22, 21 December 2014
1.60 Angstrom Resolution Crystal Structure of a 3-Dehydroquinate Dehydratase-like Protein from Bifidobacterium longum
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