1rgq: Difference between revisions

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[[Image:1rgq.gif|left|200px]]<br /><applet load="1rgq" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1rgq.gif|left|200px]]
caption="1rgq, resolution 2.90&Aring;" />
 
'''M9A HCV Protease complex with pentapeptide keto-amide inhibitor'''<br />
{{Structure
|PDB= 1rgq |SIZE=350|CAPTION= <scene name='initialview01'>1rgq</scene>, resolution 2.90&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=AKP:N-(PYRAZIN-2-YLCARBONYL)LEUCYLISOLEUCYL-N~1~-{1-[2-({1-CARBOXY-2-[4-(PHOSPHONOOXY)PHENYL]ETHYL}AMINO)-1,1-DIHYDROXY-2-OXOETHYL]BUT-3-ENYL}-3-CYCLOHEXYLALANINAMIDE'>AKP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Hepacivirin Hepacivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.98 3.4.21.98]
|GENE=
}}
 
'''M9A HCV Protease complex with pentapeptide keto-amide inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1RGQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=AKP:'>AKP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hepacivirin Hepacivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.98 3.4.21.98] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RGQ OCA].  
1RGQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RGQ OCA].  


==Reference==
==Reference==
Hepatitis C NS3 protease inhibition by peptidyl-alpha-ketoamide inhibitors: kinetic mechanism and structure., Liu Y, Stoll VS, Richardson PL, Saldivar A, Klaus JL, Molla A, Kohlbrenner W, Kati WM, Arch Biochem Biophys. 2004 Jan 15;421(2):207-16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14984200 14984200]
Hepatitis C NS3 protease inhibition by peptidyl-alpha-ketoamide inhibitors: kinetic mechanism and structure., Liu Y, Stoll VS, Richardson PL, Saldivar A, Klaus JL, Molla A, Kohlbrenner W, Kati WM, Arch Biochem Biophys. 2004 Jan 15;421(2):207-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14984200 14984200]
[[Category: Hepacivirin]]
[[Category: Hepacivirin]]
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
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[[Category: hepatitis c virus protease keto amide peptide inhibitor]]
[[Category: hepatitis c virus protease keto amide peptide inhibitor]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:50:43 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:51:26 2008''
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