1rh7: Difference between revisions
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[[Image:1rh7.gif|left|200px]] | [[Image:1rh7.gif|left|200px]] | ||
'''Crystal Structure of Resistin-like beta''' | {{Structure | ||
|PDB= 1rh7 |SIZE=350|CAPTION= <scene name='initialview01'>1rh7</scene>, resolution 3.106Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene> and <scene name='pdbligand=P6G:HEXAETHYLENE GLYCOL'>P6G</scene> | |||
|ACTIVITY= | |||
|GENE= RETNLB or FIZZ2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |||
}} | |||
'''Crystal Structure of Resistin-like beta''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1RH7 is a [ | 1RH7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RH7 OCA]. | ||
==Reference== | ==Reference== | ||
Disulfide-dependent multimeric assembly of resistin family hormones., Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L, Science. 2004 May 21;304(5674):1154-8. PMID:[http:// | Disulfide-dependent multimeric assembly of resistin family hormones., Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L, Science. 2004 May 21;304(5674):1154-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15155948 15155948] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: protein structure initiative]] | [[Category: protein structure initiative]] | ||
[[Category: psi]] | [[Category: psi]] | ||
[[Category: structural | [[Category: structural genomic]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:51:36 2008'' | ||
Revision as of 11:51, 20 March 2008
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| 1rh7, resolution 3.106Å | |||||||||||||
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| Ligands: | PT and P6G | ||||||||||||
| Gene: | RETNLB or FIZZ2 (Mus musculus) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal Structure of Resistin-like beta
Overview
Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and diabetes. Crystal structures of resistin and RELMbeta reveal an unusual multimeric structure. Each protomer comprises a carboxy-terminal disulfide-rich beta-sandwich "head" domain and an amino-terminal alpha-helical "tail" segment. The alpha-helical segments associate to form three-stranded coiled coils, and surface-exposed interchain disulfide linkages mediate the formation of tail-to-tail hexamers. Analysis of serum samples shows that resistin circulates in two distinct assembly states, likely corresponding to hexamers and trimers. Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in pancreatic-insulin clamp studies reveals substantially more potent effects on hepatic insulin sensitivity than those observed with wild-type resistin. This result suggests that processing of the intertrimer disulfide bonds may reflect an obligatory step toward activation.
About this Structure
1RH7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Disulfide-dependent multimeric assembly of resistin family hormones., Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L, Science. 2004 May 21;304(5674):1154-8. PMID:15155948
Page seeded by OCA on Thu Mar 20 13:51:36 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Mus musculus
- Single protein
- Burley, S K.
- NYSGXRC, New York Structural GenomiX Research Consortium.
- Patel, S D.
- Rajala, M W.
- Scherer, P E.
- Shapiro, L.
- P6G
- PT
- Hormone; glucose uptake; resistin/fizz family
- New york structural genomix research consortium
- Nysgxrc
- Protein structure initiative
- Psi
- Structural genomic
