4asi: Difference between revisions
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==Crystal structure of human ACACA C-terminal domain== | |||
<StructureSection load='4asi' size='340' side='right' caption='[[4asi]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
==Disease== | <table><tr><td colspan='2'>[[4asi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ASI FirstGlance]. <br> | ||
[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[http://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yl2|2yl2]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4asi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4asi RCSB], [http://www.ebi.ac.uk/pdbsum/4asi PDBsum]</span></td></tr> | |||
==Function== | </table> | ||
[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref> | == Disease == | ||
[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:[http://omim.org/entry/613933 613933]]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.<ref>PMID:6114432</ref> | |||
== | == Function == | ||
[[http://www.uniprot.org/uniprot/ACACA_HUMAN ACACA_HUMAN]] Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.<ref>PMID:20952656</ref> | |||
== References == | |||
<references/> | |||
<references | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Delft, F Von | [[Category: Delft, F Von]] | ||
[[Category: Edwards, A | [[Category: Edwards, A]] | ||
[[Category: Froese, D S | [[Category: Froese, D S]] | ||
[[Category: Kiyani, W | [[Category: Kiyani, W]] | ||
[[Category: Krojer, T | [[Category: Krojer, T]] | ||
[[Category: Muniz, J R.C | [[Category: Muniz, J R.C]] | ||
[[Category: Oppermann, U | [[Category: Oppermann, U]] | ||
[[Category: Vollmar, M | [[Category: Vollmar, M]] | ||
[[Category: Yue, W W | [[Category: Yue, W W]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
[[Category: Protein]] | [[Category: Protein]] | ||
Revision as of 09:28, 21 December 2014
Crystal structure of human ACACA C-terminal domain
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