4b03: Difference between revisions
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==6A Electron cryomicroscopy structure of immature Dengue virus serotype 1== | |||
=== | <StructureSection load='4b03' size='340' side='right' caption='[[4b03]], [[Resolution|resolution]] 6.00Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4b03]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B03 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B03 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4azx|4azx]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b03 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b03 RCSB], [http://www.ebi.ac.uk/pdbsum/4b03 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-A resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation. | |||
Immature and mature dengue serotype 1 virus structures provide insight into the maturation process.,Kostyuchenko VA, Zhang Q, Tan JL, Ng TS, Lok SM J Virol. 2013 Jul;87(13):7700-7. doi: 10.1128/JVI.00197-13. Epub 2013 May 1. PMID:23637416<ref>PMID:23637416</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dengue virus 1]] | [[Category: Dengue virus 1]] | ||
[[Category: Kostyuchenko, V A | [[Category: Kostyuchenko, V A]] | ||
[[Category: Lok, S M | [[Category: Lok, S M]] | ||
[[Category: Ng, T S | [[Category: Ng, T S]] | ||
[[Category: Tan, L C | [[Category: Tan, L C]] | ||
[[Category: Zhang, Q | [[Category: Zhang, Q]] | ||
[[Category: Flavivirus]] | [[Category: Flavivirus]] | ||
[[Category: Prm protein]] | [[Category: Prm protein]] | ||
[[Category: Virus]] | [[Category: Virus]] | ||
Revision as of 09:29, 21 December 2014
6A Electron cryomicroscopy structure of immature Dengue virus serotype 1
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