3zbo: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures== | |||
<StructureSection load='3zbo' size='340' side='right' caption='[[3zbo]], [[Resolution|resolution]] 1.58Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3zbo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZBO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZBO FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zbo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zbo RCSB], [http://www.ebi.ac.uk/pdbsum/3zbo PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The recently discovered HEAT-like repeat (HLR) DNA glycosylase superfamily is widely distributed in all domains of life. The present bioinformatics and phylogenetic analysis shows that HLR DNA glycosylase superfamily members in the genus Bacillus form three subfamilies: AlkC, AlkD and AlkF/AlkG. The crystal structure of AlkF shows structural similarity with the DNA glycosylases AlkC and AlkD, however neither AlkF nor AlkG display any DNA glycosylase activity. Instead, both proteins have affinity to branched DNA structures such as three-way and Holliday junctions. A unique beta-hairpin in the AlkF/AlkG subfamily is most likely inserted into the DNA major groove, and could be a structural determinant regulating DNA substrate affinity. We conclude that AlkF and AlkG represent a new family of HLR proteins with affinity for branched DNA structures. | |||
A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures.,Backe PH, Simm R, Laerdahl JK, Dalhus B, Fagerlund A, Okstad OA, Rognes T, Alseth I, Kolsto AB, Bjoras M J Struct Biol. 2013 Apr 25. pii: S1047-8477(13)00107-X. doi:, 10.1016/j.jsb.2013.04.007. PMID:23623903<ref>PMID:23623903</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bacillus cereus]] | [[Category: Bacillus cereus]] | ||
[[Category: Alseth, I | [[Category: Alseth, I]] | ||
[[Category: Backe, P H | [[Category: Backe, P H]] | ||
[[Category: Bjoras, M | [[Category: Bjoras, M]] | ||
[[Category: Dalhus, B | [[Category: Dalhus, B]] | ||
[[Category: Fagerlund, A | [[Category: Fagerlund, A]] | ||
[[Category: Kolsto, A B | [[Category: Kolsto, A B]] | ||
[[Category: Laerdahl, J K | [[Category: Laerdahl, J K]] | ||
[[Category: Okstad, O A | [[Category: Okstad, O A]] | ||
[[Category: Rognes, T | [[Category: Rognes, T]] | ||
[[Category: Simm, R | [[Category: Simm, R]] | ||
[[Category: Alkc]] | [[Category: Alkc]] | ||
[[Category: Alkd]] | [[Category: Alkd]] | ||
