1rqi: Difference between revisions

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[[Image:1rqi.gif|left|200px]]<br /><applet load="1rqi" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1rqi.gif|left|200px]]
caption="1rqi, resolution 2.42&Aring;" />
 
'''Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Dimethylallyl S-Thiolodiphosphate'''<br />
{{Structure
|PDB= 1rqi |SIZE=350|CAPTION= <scene name='initialview01'>1rqi</scene>, resolution 2.42&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=DST:DIMETHYLALLYL+S-THIOLODIPHOSPHATE'>DST</scene>, <scene name='pdbligand=IPR:ISOPENTYL+PYROPHOSPHATE'>IPR</scene> and <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Geranyltranstransferase Geranyltranstransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10]
|GENE= ISPA, B0421 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Dimethylallyl S-Thiolodiphosphate'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1RQI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=DST:'>DST</scene>, <scene name='pdbligand=IPR:'>IPR</scene> and <scene name='pdbligand=DPO:'>DPO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Geranyltranstransferase Geranyltranstransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.10 2.5.1.10] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQI OCA].  
1RQI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQI OCA].  


==Reference==
==Reference==
Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis., Hosfield DJ, Zhang Y, Dougan DR, Broun A, Tari LW, Swanson RV, Finn J, J Biol Chem. 2004 Mar 5;279(10):8526-9. Epub 2003 Dec 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14672944 14672944]
Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis., Hosfield DJ, Zhang Y, Dougan DR, Broun A, Tari LW, Swanson RV, Finn J, J Biol Chem. 2004 Mar 5;279(10):8526-9. Epub 2003 Dec 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14672944 14672944]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Geranyltranstransferase]]
[[Category: Geranyltranstransferase]]
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[[Category: isoprenyl synthase]]
[[Category: isoprenyl synthase]]


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