1rr8: Difference between revisions

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[[Image:1rr8.gif|left|200px]]<br /><applet load="1rr8" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1rr8.gif|left|200px]]
caption="1rr8, resolution 2.6&Aring;" />
 
'''Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I'''<br />
{{Structure
|PDB= 1rr8 |SIZE=350|CAPTION= <scene name='initialview01'>1rr8</scene>, resolution 2.6&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=TTG:2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID'>TTG</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/DNA_topoisomerase DNA topoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.2 5.99.1.2]
|GENE= TOP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1RR8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=TTG:'>TTG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/DNA_topoisomerase DNA topoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.2 5.99.1.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RR8 OCA].  
1RR8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RR8 OCA].  


==Reference==
==Reference==
Mechanisms of camptothecin resistance by human topoisomerase I mutations., Chrencik JE, Staker BL, Burgin AB, Pourquier P, Pommier Y, Stewart L, Redinbo MR, J Mol Biol. 2004 Jun 11;339(4):773-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15165849 15165849]
Mechanisms of camptothecin resistance by human topoisomerase I mutations., Chrencik JE, Staker BL, Burgin AB, Pourquier P, Pommier Y, Stewart L, Redinbo MR, J Mol Biol. 2004 Jun 11;339(4):773-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15165849 15165849]
[[Category: DNA topoisomerase]]
[[Category: DNA topoisomerase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: topotecan]]
[[Category: topotecan]]


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