4fpp: Difference between revisions
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==Bacterial phosphotransferase== | |||
=== | <StructureSection load='4fpp' size='340' side='right' caption='[[4fpp]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4fpp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_crescentus_cb15 Caulobacter crescentus cb15]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FPP FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CC_3470 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=190650 Caulobacter crescentus CB15])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fpp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fpp RCSB], [http://www.ebi.ac.uk/pdbsum/4fpp PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Two-component and phosphorelay signal-transduction proteins are crucial for bacterial cell-cycle regulation in Caulobacter crescentus. ChpT is an essential histidine phosphotransferase that controls the activity of the master cell-cycle regulator CtrA by phosphorylation. Here, the 2.2 A resolution crystal structure of ChpT is reported. ChpT is a homodimer and adopts the domain architecture of the intracellular part of class I histidine kinases. Each subunit consists of two distinct domains: an N-terminal helical hairpin domain and a C-terminal alpha/beta domain. The two N-terminal domains are adjacent within the dimer, forming a four-helix bundle. The ChpT C-terminal domain adopts an atypical Bergerat ATP-binding fold. | |||
Structural insights into ChpT, an essential dimeric histidine phosphotransferase regulating the cell cycle in Caulobacter crescentus.,Fioravanti A, Clantin B, Dewitte F, Lens Z, Verger A, Biondi EG, Villeret V Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Sep 1;68(Pt 9):1025-9., doi: 10.1107/S1744309112033064. Epub 2012 Aug 29. PMID:22949187<ref>PMID:22949187</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | |||
*[[Phosphotransferase|Phosphotransferase]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caulobacter crescentus cb15]] | [[Category: Caulobacter crescentus cb15]] | ||
[[Category: Biondi, E | [[Category: Biondi, E]] | ||
[[Category: Clantin, B | [[Category: Clantin, B]] | ||
[[Category: Dewitte, F | [[Category: Dewitte, F]] | ||
[[Category: Fioravanti, A | [[Category: Fioravanti, A]] | ||
[[Category: Lens, Z | [[Category: Lens, Z]] | ||
[[Category: Verger, A | [[Category: Verger, A]] | ||
[[Category: Villeret, V | [[Category: Villeret, V]] | ||
[[Category: Bacterial cytoplasme]] | [[Category: Bacterial cytoplasme]] | ||
[[Category: Bergerat fold]] | [[Category: Bergerat fold]] | ||
