4efe: Difference between revisions

Line 1:

~~{{STRUCTURE_4efe~~| ~~PDB~~=4efe | ~~SCENE~~= }}

==crystal structure of DNA ligase==

===~~crystal structure of~~ DNA ligase===

== Structural highlights ==

<table><tr><td colspan='2'>[[4efe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFE OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EFE FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=0OV:[4-AMINO-2-{[(1S,2R)-2-METHYLCYCLOHEXYL]OXY}-5-OXOPYRIDO[2,3-D]PYRIMIDIN-8(5H)-YL]ACETONITRILE'>0OV</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4eeq|4eeq]]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/DNA_ligase_(NAD(+)) DNA ligase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.2 6.5.1.2] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4efe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4efe RCSB], [http://www.ebi.ac.uk/pdbsum/4efe PDBsum]</td></tr>

</table>

==~~Function~~==

==See Also==

[[~~http://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA]]~~ DNA ligase ~~that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded~~ DNA ~~using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).~~

*[[DNA ligase|DNA ligase]]

__TOC__

~~==About this Structure==~~

</StructureSection>

[[4efe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/~~ocashort?id=4EFE OCA].~~

[[Category: Enterococcus faecalis]]

[[Category: Charifson, P.]]

[[Category: Charifson, P]]

[[Category: Wang, T.]]

[[Category: Wang, T]]

[[Category: Wei, Y.]]

[[Category: Wei, Y]]

[[Category: Xu, W.]]

[[Category: Xu, W]]

[[Category: Adenylation]]

[[Category: Alpha-beta protein]]

[[Category: Dna ligase]]

[[Category: Ligase-ligase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4efe|  PDB=4efe  |  SCENE=  }}
+==crystal structure of DNA ligase==
-===crystal structure of DNA ligase===
+<StructureSection load='4efe' size='340' side='right' caption='[[4efe]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4efe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EFE FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0OV:[4-AMINO-2-{[(1S,2R)-2-METHYLCYCLOHEXYL]OXY}-5-OXOPYRIDO[2,3-D]PYRIMIDIN-8(5H)-YL]ACETONITRILE'>0OV</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eeq|4eeq]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(NAD(+)) DNA ligase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.2 6.5.1.2] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4efe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4efe RCSB], [http://www.ebi.ac.uk/pdbsum/4efe PDBsum]</span></td></tr>
+</table>
-==Function==
+==See Also==
-[[http://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
+*[[DNA ligase|DNA ligase]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[4efe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFE OCA].
 [[Category: Enterococcus faecalis]]
-[[Category: Charifson, P.]]
+[[Category: Charifson, P]]
-[[Category: Wang, T.]]
+[[Category: Wang, T]]
-[[Category: Wei, Y.]]
+[[Category: Wei, Y]]
-[[Category: Xu, W.]]
+[[Category: Xu, W]]
 [[Category: Adenylation]]
 [[Category: Alpha-beta protein]]
 [[Category: Dna ligase]]
 [[Category: Ligase-ligase inhibitor complex]]