1rv1: Difference between revisions

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[[Image:1rv1.gif|left|200px]]<br /><applet load="1rv1" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1rv1.gif|left|200px]]
caption="1rv1, resolution 2.30&Aring;" />
 
'''CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR'''<br />
{{Structure
|PDB= 1rv1 |SIZE=350|CAPTION= <scene name='initialview01'>1rv1</scene>, resolution 2.30&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=IMZ:CIS-[4,5-BIS-(4-BROMOPHENYL)-2-(2-ETHOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE'>IMZ</scene>
|ACTIVITY=
|GENE= MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1RV1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=IMZ:'>IMZ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RV1 OCA].  
1RV1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RV1 OCA].  


==Reference==
==Reference==
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2., Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA, Science. 2004 Feb 6;303(5659):844-8. Epub 2004 Jan 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14704432 14704432]
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2., Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA, Science. 2004 Feb 6;303(5659):844-8. Epub 2004 Jan 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14704432 14704432]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein-protein interaction]]
[[Category: protein-protein interaction]]


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