1ryw: Difference between revisions

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[[Image:1ryw.gif|left|200px]]<br /><applet load="1ryw" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ryw.gif|left|200px]]
caption="1ryw, resolution 2.3&Aring;" />
 
'''C115S MurA liganded with reaction products'''<br />
{{Structure
|PDB= 1ryw |SIZE=350|CAPTION= <scene name='initialview01'>1ryw</scene>, resolution 2.3&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=EPU:URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL)+BUTYRIC+ACID'>EPU</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/UDP-N-acetylglucosamine_1-carboxyvinyltransferase UDP-N-acetylglucosamine 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.7 2.5.1.7]
|GENE= MURA, MURZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=550 Enterobacter cloacae])
}}
 
'''C115S MurA liganded with reaction products'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1RYW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=EPU:'>EPU</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/UDP-N-acetylglucosamine_1-carboxyvinyltransferase UDP-N-acetylglucosamine 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.7 2.5.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RYW OCA].  
1RYW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RYW OCA].  


==Reference==
==Reference==
Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release., Eschenburg S, Priestman M, Schonbrunn E, J Biol Chem. 2005 Feb 4;280(5):3757-63. Epub 2004 Nov 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15531591 15531591]
Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release., Eschenburg S, Priestman M, Schonbrunn E, J Biol Chem. 2005 Feb 4;280(5):3757-63. Epub 2004 Nov 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15531591 15531591]
[[Category: Enterobacter cloacae]]
[[Category: Enterobacter cloacae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: inside-out alpha-beta barrel]]
[[Category: inside-out alpha-beta barrel]]


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