4j7p: Difference between revisions

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{{STRUCTURE_4j7p| PDB=4j7p | SCENE= }}
==Crystal structure of Saccharomyces cerevisiae Sfh3==
===Crystal structure of Saccharomyces cerevisiae Sfh3===
<StructureSection load='4j7p' size='340' side='right' caption='[[4j7p]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
{{ABSTRACT_PUBMED_23603387}}
== Structural highlights ==
<table><tr><td colspan='2'>[[4j7p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J7P FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j7q|4j7q]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">N1158, PDR16, SFH3, YNL231C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j7p RCSB], [http://www.ebi.ac.uk/pdbsum/4j7p PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Sec14 family homologs are the major yeast phosphatidylinositol/phosphatidylcholine transfer proteins regulating lipid metabolism and vesicle trafficking. The structure of Saccharomyces cerevisiae Sfh3 displays a conserved Sec14 scaffold and reveals determinants for the specific recognition of phosphatidylinositol ligand. Apo-Sfh3 forms a dimer through the hydrophobic interaction of gating helices. Binding of phosphatidylinositol leads to dissociation of the dimer into monomers in a reversible manner. This study suggests that the substrate induced dimer-monomer transformation is an essential part of lipid transfer cycles by Sfh3.


==Function==
Structural determinants for phosphatidylinositol recognition by Sfh3 and substrate-induced dimer-monomer transition during lipid transfer cycles.,Yang H, Tong J, Leonard TA, Im YJ FEBS Lett. 2013 Jun 5;587(11):1610-6. doi: 10.1016/j.febslet.2013.04.009. Epub, 2013 Apr 18. PMID:23603387<ref>PMID:23603387</ref>
[[http://www.uniprot.org/uniprot/PDR16_YEAST PDR16_YEAST]] Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover.<ref>PMID:9890948</ref> <ref>PMID:10848624</ref>


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[4j7p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7P OCA].
</div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:023603387</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Im, Y J.]]
[[Category: Im, Y J]]
[[Category: Yang, H.]]
[[Category: Yang, H]]
[[Category: Lipid transport]]
[[Category: Lipid transport]]
[[Category: Phosphatidylinositol]]
[[Category: Phosphatidylinositol]]
[[Category: Sec14 scaffold]]
[[Category: Sec14 scaffold]]
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