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{{STRUCTURE_4jdl|  PDB=4jdl  |  SCENE=  }}
==Crystal structure of native abscisic acid receptor PYL5 at 2.65 Angstrom==
===Crystal structure of native abscisic acid receptor PYL5 at 2.65 Angstrom===
<StructureSection load='4jdl' size='340' side='right' caption='[[4jdl]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
{{ABSTRACT_PUBMED_23844015}}
== Structural highlights ==
<table><tr><td colspan='2'>[[4jdl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qrz 3qrz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JDL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3klx|3klx]], [[3oqu|3oqu]], [[3kl1|3kl1]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYL5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jdl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jdl RCSB], [http://www.ebi.ac.uk/pdbsum/4jdl PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The phytohormone abscisic acid ((+)-ABA) plays a key role in many processes. The biological and biochemical activities of unnatural (-)-ABA have been extensively investigated since 1960s. However, the recognition mechanism by which only a few members among PYR/PYL/RCAR (PYLs) family can bind (-)-ABA remains largely unknown. Here we systematically characterized the affinity of PYLs binding to the (-)-ABA and reported the crystal structures of apo-PYL5, PYL3-(-)-ABA and PYL9-(+)-ABA. PYL5 showed the strongest binding affinity with (-)-ABA among all the PYLs. PYL9 is a stringently exclusive (+)-ABA receptor with interchangeable disulfide bonds shared by a subclass of PYLs. PYL3 is a dual receptor to both ABA enantiomers. The binding orientation and pocket of (-)-ABA in PYLs are obviously different from those of (+)-ABA. Steric hindrance and hydrophobic interaction are the two key factors in determining the stereospecificity of PYLs binding to (-)-ABA, which is further confirmed by gain-of-function and loss-of-function mutagenesis. Our results provide novel insights of the bioactivity of ABA enantiomers onto PYLs, and shed light on designing the selective ABA receptors agonists.


==Function==
Structural Insights into the Abscisic Acid Stereospecificity by the ABA Receptors PYR/PYL/RCAR.,Zhang X, Jiang L, Wang G, Yu L, Zhang Q, Xin Q, Wu W, Gong Z, Chen Z PLoS One. 2013 Jul 2;8(7):e67477. doi: 10.1371/journal.pone.0067477. Print 2013. PMID:23844015<ref>PMID:23844015</ref>
[[http://www.uniprot.org/uniprot/PYL5_ARATH PYL5_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA. Confers enhanced sensitivity to ABA.<ref>PMID:19624469</ref> <ref>PMID:19407143</ref>


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[4jdl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qrz 3qrz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JDL OCA].
</div>


==Reference==
==See Also==
<ref group="xtra">PMID:023844015</ref><references group="xtra"/><references/>
*[[PYR/PYL/RCAR family of ABA receptors|PYR/PYL/RCAR family of ABA receptors]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Chen, Z.]]
[[Category: Chen, Z]]
[[Category: Zhang, Q.]]
[[Category: Zhang, Q]]
[[Category: Zhang, X.]]
[[Category: Zhang, X]]
[[Category: Abscisic acid receptor]]
[[Category: Abscisic acid receptor]]
[[Category: Hormone receptor]]
[[Category: Hormone receptor]]
[[Category: Pp2c]]
[[Category: Pp2c]]
Retrieved from "https://proteopedia.org/4jdl"