4jf2: Difference between revisions
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==Structure of a class II preQ1 riboswitch reveals ligand recognition by a new fold== | |||
<StructureSection load='4jf2' size='340' side='right' caption='[[4jf2]], [[Resolution|resolution]] 2.28Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4jf2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JF2 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PRF:7-DEAZA-7-AMINOMETHYL-GUANINE'>PRF</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jf2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jf2 RCSB], [http://www.ebi.ac.uk/pdbsum/4jf2 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
PreQ1 riboswitches regulate genes by binding the pyrrolopyrimidine intermediate preQ1 during the biosynthesis of the essential tRNA base queuosine. We report what is to our knowledge the first preQ1-II riboswitch structure at 2.3-A resolution, which uses a previously uncharacterized fold to achieve effector recognition at the confluence of a three-way helical junction flanking a pseudoknotted ribosome-binding site. The results account for translational control mediated by the preQ1-II riboswitch class and expand the known repertoire of ligand-binding modes used by regulatory RNAs. | |||
Structure of a class II preQ riboswitch reveals ligand recognition by a new fold.,Liberman JA, Salim M, Krucinska J, Wedekind JE Nat Chem Biol. 2013 Apr 14. doi: 10.1038/nchembio.1231. PMID:23584677<ref>PMID:23584677</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
[[Category: Liberman, J A | |||
[[Category: Wedekind, J E | ==See Also== | ||
*[[Riboswitch|Riboswitch]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Liberman, J A]] | |||
[[Category: Wedekind, J E]] | |||
[[Category: H-type pseudoknot]] | [[Category: H-type pseudoknot]] | ||
[[Category: Riboswitch]] | [[Category: Riboswitch]] | ||
[[Category: Rna]] | [[Category: Rna]] | ||
Revision as of 12:49, 21 December 2014
Structure of a class II preQ1 riboswitch reveals ligand recognition by a new fold
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