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{{STRUCTURE_4hsc|  PDB=4hsc  |  SCENE=  }}
==Crystal structure of a cholesterol dependent cytolysin==
===Crystal structure of a cholesterol dependent cytolysin===
<StructureSection load='4hsc' size='340' side='right' caption='[[4hsc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4hsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_ssi-1 Streptococcus pyogenes ssi-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HSC FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/TACY_STRPQ TACY_STRPQ]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).  
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">slo, SPs0132 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=193567 Streptococcus pyogenes SSI-1])</td></tr>
 
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hsc RCSB], [http://www.ebi.ac.uk/pdbsum/4hsc PDBsum]</span></td></tr>
[[4hsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_ssi-1 Streptococcus pyogenes ssi-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSC OCA].  
</table>
__TOC__
</StructureSection>
[[Category: Streptococcus pyogenes ssi-1]]
[[Category: Streptococcus pyogenes ssi-1]]
[[Category: Feil, S C.]]
[[Category: Feil, S C]]
[[Category: Parker, M W.]]
[[Category: Parker, M W]]
[[Category: Cholesterol-dependent cytolysin]]
[[Category: Cholesterol-dependent cytolysin]]
[[Category: Membrane insertion]]
[[Category: Membrane insertion]]
[[Category: Membrane pore]]
[[Category: Membrane pore]]
[[Category: Pore-forming toxin]]
[[Category: Pore-forming toxin]]
[[Category: Pore-forming toxin]]
[[Category: Toxin]]
[[Category: Toxin]]

Revision as of 13:04, 21 December 2014

Crystal structure of a cholesterol dependent cytolysin

4hsc, resolution 2.10Å

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