1sa5: Difference between revisions

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[[Image:1sa5.gif|left|200px]]<br /><applet load="1sa5" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1sa5.gif|left|200px]]
caption="1sa5, resolution 2.60&Aring;" />
 
'''Rat protein farnesyltransferase complexed with FPP and BMS-214662'''<br />
{{Structure
|PDB= 1sa5 |SIZE=350|CAPTION= <scene name='initialview01'>1sa5</scene>, resolution 2.60&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=BMV:3-BENZYL-1-(1H-IMIDAZOL-4-YLMETHYL)-4-(THIEN-2-YLSULFONYL)-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>BMV</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58]
|GENE= FNTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), FNTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
}}
 
'''Rat protein farnesyltransferase complexed with FPP and BMS-214662'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1SA5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=FPP:'>FPP</scene>, <scene name='pdbligand=BMV:'>BMV</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein_farnesyltransferase Protein farnesyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.58 2.5.1.58] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SA5 OCA].  
1SA5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SA5 OCA].  


==Reference==
==Reference==
Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity., Reid TS, Beese LS, Biochemistry. 2004 Jun 8;43(22):6877-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15170324 15170324]
Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity., Reid TS, Beese LS, Biochemistry. 2004 Jun 8;43(22):6877-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15170324 15170324]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Protein farnesyltransferase]]
[[Category: Protein farnesyltransferase]]
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[[Category: lipid modification]]
[[Category: lipid modification]]
[[Category: protein prenylation]]
[[Category: protein prenylation]]
[[Category: ras]]
[[Category: ra]]
[[Category: tumor regression]]
[[Category: tumor regression]]


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