4lg7: Difference between revisions

Line 1:

~~{{STRUCTURE_4lg7| PDB=4lg7 | SCENE= }}~~

==Crystal structure MBD4 MBD domain in complex with methylated CpG DNA==

===Crystal structure MBD4 MBD domain in complex with methylated CpG DNA===

== Structural highlights ==

<table><tr><td colspan='2'>[[4lg7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG7 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LG7 FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">MBD4, MED1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lg7 RCSB], [http://www.ebi.ac.uk/pdbsum/4lg7 PDBsum]</td></tr>

</table>

==~~Function~~==

==See Also==

[[http://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN]] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG ~~sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-~~CpG-binding protein~~.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref>~~

*[[Methyl CpG binding protein|Methyl CpG binding protein]]

__TOC__

~~==About this Structure==~~

</StructureSection>

~~[[4lg7~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG7 OCA].

~~==Reference==~~

~~<references group="xtra"/>~~<~~references~~/>

[[Category: Homo sapiens]]

[[Category: Arrowsmith, C H.]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C.]]

[[Category: Bountra, C]]

[[Category: Edwards, A M.]]

[[Category: Edwards, A M]]

[[Category: Min, J.]]

[[Category: Min, J]]

[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]

[[Category: Structural genomic]]

[[Category: Tempel, W.]]

[[Category: Tempel, W]]

[[Category: Wernimont, A K.]]

[[Category: Wernimont, A K]]

[[Category: Xu, C.]]

[[Category: Xu, C]]

[[Category: Hydrolase-dna complex]]

[[Category: Sgc]]

~~[[Category: Structural genomics consortium]]~~

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4lg7|  PDB=4lg7  |  SCENE=  }}
+==Crystal structure MBD4 MBD domain in complex with methylated CpG DNA==
-===Crystal structure MBD4 MBD domain in complex with methylated CpG DNA===
+<StructureSection load='4lg7' size='340' side='right' caption='[[4lg7]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4lg7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LG7 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MBD4, MED1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lg7 RCSB], [http://www.ebi.ac.uk/pdbsum/4lg7 PDBsum]</span></td></tr>
+</table>
-==Function==
+==See Also==
-[[http://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN]] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref>
+*[[Methyl CpG binding protein|Methyl CpG binding protein]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[4lg7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG7 OCA].
-==Reference==
-<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith, C H]]
-[[Category: Bountra, C.]]
+[[Category: Bountra, C]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards, A M]]
-[[Category: Min, J.]]
+[[Category: Min, J]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Structural genomic]]
-[[Category: Tempel, W.]]
+[[Category: Tempel, W]]
-[[Category: Wernimont, A K.]]
+[[Category: Wernimont, A K]]
-[[Category: Xu, C.]]
+[[Category: Xu, C]]
 [[Category: Hydrolase-dna complex]]
 [[Category: Sgc]]
-[[Category: Structural genomics consortium]]