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{{STRUCTURE_4lc7| PDB=4lc7 | SCENE= }}
==Aminooxazoline inhibitor of BACE-1==
===Aminooxazoline inhibitor of BACE-1===
<StructureSection load='4lc7' size='340' side='right' caption='[[4lc7]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LC7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1WP:(3AR,7AR)-3A-[3-(5-CHLOROPYRIDIN-3-YL)PHENYL]-3A,4,5,6,7,7A-HEXAHYDRO-1,3-BENZOXAZOL-2-AMINE'>1WP</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l7g|4l7g]], [[4l7j|4l7j]], [[4l7h|4l7h]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lc7 RCSB], [http://www.ebi.ac.uk/pdbsum/4lc7 PDBsum]</span></td></tr>
</table>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> 
*[[Beta secretase|Beta secretase]]
 
__TOC__
==About this Structure==
</StructureSection>
[[4lc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LC7 OCA].
 
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
[[Category: Dutcher, D.]]
[[Category: Dutcher, D]]
[[Category: Huestis, M P.]]
[[Category: Huestis, M P]]
[[Category: Hunt, K W.]]
[[Category: Hunt, K W]]
[[Category: Liu, W.]]
[[Category: Liu, W]]
[[Category: Purkey, H E.]]
[[Category: Purkey, H E]]
[[Category: Siu, M.]]
[[Category: Siu, M]]
[[Category: Smith, D.]]
[[Category: Smith, D]]
[[Category: Vigers, G P.A.]]
[[Category: Vigers, G P.A]]
[[Category: Volgraf, M.]]
[[Category: Volgraf, M]]
[[Category: Wang, W.]]
[[Category: Wang, W]]
[[Category: Wu, C.]]
[[Category: Wu, C]]
[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
Retrieved from "https://proteopedia.org/4lc7"