4juy: Difference between revisions

Line 1:

~~{{STRUCTURE_4juy| PDB=4juy | SCENE= }}~~

==Crystal structure of the PUB domain of E3 ubiquitin ligase RNF31==

===Crystal structure of the PUB domain of E3 ubiquitin ligase RNF31===

== Structural highlights ==

<table><tr><td colspan='2'>[[4juy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUY OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JUY FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">RNF31, ZIBRA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4juy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4juy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4juy RCSB], [http://www.ebi.ac.uk/pdbsum/4juy PDBsum]</td></tr>

</table>

==~~Function~~==

==See Also==

[[~~http://www.uniprot.org/uniprot/RNF31_HUMAN RNF31_HUMAN]] E3 ubiquitin-~~protein ligase component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.<ref>PMID:17006537</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref> <ref>PMID:22863777</ref>

*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]

__TOC__

~~==About this Structure==~~

</StructureSection>

~~[[4juy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUY OCA~~].

~~==Reference==~~

~~<references group="xtra"/>~~<~~references~~/>

[[Category: Homo sapiens]]

[[Category: Arrowsmith, C H.]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C.]]

[[Category: Bountra, C]]

[[Category: Dong, A.]]

[[Category: Dong, A]]

[[Category: Edwards, A M.]]

[[Category: Edwards, A M]]

[[Category: Hu, J.]]

[[Category: Hu, J]]

[[Category: Li, Y.]]

[[Category: Li, Y]]

[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]

[[Category: Structural genomic]]

[[Category: Tong, Y.]]

[[Category: Tong, Y]]

[[Category: Wernimont, A.]]

[[Category: Wernimont, A]]

[[Category: E3 ubiquitin ligase]]

[[Category: Pub domain]]

[[Category: Sgc]]

~~[[Category: Structural genomic]]~~

~~[[Category: Structural genomics consortium]]~~

[[Category: Unknown function]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4juy|  PDB=4juy  |  SCENE=  }}
+==Crystal structure of the PUB domain of E3 ubiquitin ligase RNF31==
-===Crystal structure of the PUB domain of E3 ubiquitin ligase RNF31===
+<StructureSection load='4juy' size='340' side='right' caption='[[4juy]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4juy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JUY FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RNF31, ZIBRA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4juy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4juy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4juy RCSB], [http://www.ebi.ac.uk/pdbsum/4juy PDBsum]</span></td></tr>
+</table>
-==Function==
+==See Also==
-[[http://www.uniprot.org/uniprot/RNF31_HUMAN RNF31_HUMAN]] E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.<ref>PMID:17006537</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref> <ref>PMID:22863777</ref>
+*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[4juy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUY OCA].
-==Reference==
-<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith, C H]]
-[[Category: Bountra, C.]]
+[[Category: Bountra, C]]
-[[Category: Dong, A.]]
+[[Category: Dong, A]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards, A M]]
-[[Category: Hu, J.]]
+[[Category: Hu, J]]
-[[Category: Li, Y.]]
+[[Category: Li, Y]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Structural genomic]]
-[[Category: Tong, Y.]]
+[[Category: Tong, Y]]
-[[Category: Wernimont, A.]]
+[[Category: Wernimont, A]]
 [[Category: E3 ubiquitin ligase]]
 [[Category: Pub domain]]
 [[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
 [[Category: Unknown function]]